Clinical trial · Interventional
Endostar Combined With Concurrent Chemoradiotherapy For Locally Advanced Cervical Carcinoma
A Multicenter, Randomized Controlled Clinical Trial Comparing Endostar With Concurrent Chemoradiotherapy Versus Concurrent Chemoradiotherapy in the Treatment of Locally Advanced Cervical Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A total of 120 patients with pathologically confirmed Locally advanced cervical carcinoma were enrolled. Patients were randomly divided into two groups, with 60 patients in each group. One group was treated with Concurrent Chemoradiotherapy combined with Endostar and the other group was treated with Concurrent Chemoradiotherapy. The short term efficacy and the toxic of these treatments were evaluated. The 1-year, 3-year, 5-year overall survival and progression-free survival of patients were analyzed. The investigators data may provide an alternative option for the treatment of Locally advanced cervical carcinoma with high efficacy and low toxicity.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Carcinoma | Cervical Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| DDP | Drug | Cisplatin | ALIAS |
| Endostar | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- concurrent chemoradiotherapy + endostar
- description
- 4 cycles of Endostar and 5 cycles of DDP concurrent with radiotherapy
- interventionNames
- Drug: Endostar
- Drug: DDP
- type
- ACTIVE_COMPARATOR
- label
- concurrent chemoradiotherapy
- description
- 5 cycles of DDP concurrent with radiotherapy
- interventionNames
- Drug: DDP
Primary outcomes (1)
- measure
- short-time effect
- timeFrame
- 3 months
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * patients of either gender and aged from 18 to 65 years old. * patients with histologically confirmed cervical carcinoma. * patients at stage Ib, IIa2, IIb-IVa by FIGO 2009 staging. * KPS ≥ 70 (Appendix I) * patients with available MRI or CT data of cervical and measurable tumor lesions. * patients did not receive any treatment before enrollment. * patients with expected survival longer than 6 months. * biochemical indexes: WBC \> 4,000/mm3, and blood platelet ≥ 100,000 mm3; PT≤UNL; levels of indicators for hepatic and renal function was 1.5 folds of the upper limit of normal value. * the informed content was obtained from every patient. * patients with effective follow-up. Exclusion Criteria: * those with malignant tumors other than cervical carcinoma. * those received treatments before enrollmment. * lactating women and Pregnant woman. * those who were undergoing other drug trials. * those with severe complications, including myocardial infarction, severe arrhythmia, severe cerebrovascular disease, ulcer disease, mental illness and uncontrollable diabetes. * those who were treated with tumor targeting drugs. * those who could not subject to MRI or CT examination. * those who could not meet the requirements of the prescribed dose.
References
Publications (1)
- DERIVEDWu F, Tang X, Liu W, Luo Z, Huang H, Liu M, Wang H, Liao S, Ma S, Jiang L, Zhang Y. Efficacy of Endostar plus concurrent chemoradiotherapy in locally advanced cervical cancer: a multicenter, phase II randomized trial. Ther Adv Med Oncol. 2025 Oct 3;17:17588359251379397. doi: 10.1177/17588359251379397. eCollection 2025. PMID 41049580