Clinical trial · Interventional
Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated Patients
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
In mitotane treated patients, serum cortisol cannot be used to diagnose hypoadrenalism, since mitotane increases cortisol binding globulin levels (CBG), artificially raising total cortisol. Salivary free cortisol (SC) is not affected by CBG alterations, and reflects the free serum cortisol. In the current study, investigators will assess serum and SC responses during low-dose cosyntropin stimulation test in healthy volunteers, mitotane-induced hypoadrenal patients on steroid replacement therapy and in patients who suffer from hypoadrenlism caused from other etiology. Investigators will compare results between groups and try to demonstrate the superiority of SC in assessing adrenal function in mitotane treated patients.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adrenal Cancer | Malignant Adrenal Gland Neoplasm | ALIAS | 0.90 |
| Adrenal Insufficiency | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cosyntropin stimulation test | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- EXPERIMENTAL
- label
- healthy subjects
- description
- low-dose cosyntropin stimulation test
- interventionNames
- Diagnostic Test: Cosyntropin stimulation test
- type
- EXPERIMENTAL
- label
- hypoadrenal mitotane treated patients
- description
- low-dose cosyntropin stimulation test
- interventionNames
- Diagnostic Test: Cosyntropin stimulation test
- type
- EXPERIMENTAL
- label
- hypoadrenal no-mitotane treated patients
- description
- low-dose cosyntropin stimulation test
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * mitotane treated * known hypoadrenlism Exclusion Criteria: * pregnancy
References
Publications (0)
Data not yet available