Clinical trial · Observational
Prediction Model of Response for CCRT in Esophageal Cancer
Prediction Model of Response for Combined Chemo-Radio-therapy Based on Clinical and Molecular Biology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
1. Retrospective review of old patients * Analysis of prediction factors for concomitant chemo-radiotherapy in locally advanced and advanced esophageal cancer from 2005 to 2015 2. Prospective case-control study: RNA sequencing \& miRNA microarray * naive esophageal cancer patients who have a plan to receive concomitant chemo-radiotherapy * acquirement of tissue, blood, clinical information * isolation of RNA, DNA, serum database of clinical \& demographic information \*\*\*Analysis of mRNA sequencing / miRNA sequencing\*\*\*\* first analysis of RNA sequencing: bioinformatician second analysis of RNA sequencing: principle investigator 3. Experimental set for qPCR (esophageal tissue) study group 4. TMA for screened exon gene 5. validation set for qPCR (esophageal tissue) 6. follow-up of circulating miRNA in blood (baseline blood \& post-CCRT blood 3M, 6M, 12M) 7. Prediction model for CCRT response in esophageal Cancer based on clinical and molecular factors 8. Validate the prediction model.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Cancer | Malignant Esophageal Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| chemoradiotherapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Responder
- description
- Complete Remission after chemoradiotherapy in locally advanced or advanced esophageal cancer evaluation of disease status: endoscopy, CT, and/or PET-CT
- interventionNames
- Other: chemoradiotherapy
- label
- non-responder
- description
- Progressive disease or stationary state after chemoradiotherapy in locally advanced or advanced esophageal cancer evaluation of disease status: endoscopy, CT, and/or PET-CT
- interventionNames
- Other: chemoradiotherapy
Primary outcomes (1)
- measure
- Prediction model for CCRT response based on clinical and genetic molecular factors
- timeFrame
- up to 36 months
- description
- prediction model for CCRT response based on clinical and genetic molecular factors in esophageal cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. locally advanced or advanced esophageal cancer who want concomitant chemoradiotherapy 2. persons who assigned the written informed consents. Exclusion Criteria: 1. persons who did't assign the informed consents 2. other organ cancer 3. heavy alcoholics
References
Publications (0)
Data not yet available