Clinical trial · Interventional
Regional Anaesthesia and Substance P in Head and Neck Cancer
Influence of Regional Anaesthesia on the Expression of Substance P During Unilateral Neck Dissection Due to Head and Neck Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): for organizational reasons
Summary
Brief summary (as posted)
In the clinical trial the investigators will observe the impact of regional anesthesia in addition to a general anesthesia on the expression of substance P in patients with unilateral Head or Neck cancer undergoing unilateral Neck Dissection. The investigators will perform an unilateral regional cervical plexus block on the tumor side. The tissue of the tumor side will be analysed by immunohistology, measuring the expression of the Substance P.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancer | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| SPRANC Block group | Drug | — | UNRESOLVED |
| SPRANC Control group | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- SPRANC Block group
- description
- General anaesthesia and additional regional anaesthesia (cervical plexus block) on the tumor side.
- interventionNames
- Drug: SPRANC Block group
- type
- ACTIVE_COMPARATOR
- label
- SPRANC Control group
- description
- General anaesthesia
- interventionNames
- Drug: SPRANC Control group
Primary outcomes (1)
- measure
- Expression of Substance P
- timeFrame
- 2 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients at Charité - Universitaetsmedizin Berlin, Campus Charité Mitte * Primary diagnosis of unilateral head or neck cancer * Resection of Tumor is planned with unilateral neck dissection * Patient did not underwent any therapeutic treatment of the cancer before start of study * Surgical therapy is planned with curative intent Exclusion Criteria: * Allergy to local anesthetics * Coagulation disorders, which can lead to complications in regional anesthesia * Insulin-dependent diabetes mellitus, polyneuropathy * Severe psychiatric disorders * Dementia * Alcohol abuse, Korsakoff syndrome * Medication with immunosuppressants or immune modulantia * Patient under Special Care * Refusal of study participation * Pregnancy and breast feeding period. * Participation in a clinical intervention study, parallel with the study or participation up to 30 days before inclusion * Lack of consent that pseudonomized data of the study may be saved and distributed
References
Publications (0)
Data not yet available