Discovery and Validation of Plasma DNA Methylation Biomarker for Detection of Stomach Cancer

Background: Stomach cancer is common around the world. The US is a low-risk region. But the 5-year survival rate in the US is low. This is because the cancer is usually in a late stage by the time it is diagnosed. One way to detect it earlier is to screen many people with a procedure called endoscopy. But this may not be feasible in low-risk or developing countries. Researchers want to find a biomarker for early-stage disease to help them create an effective way of screening. DNA methylation is a chemical modification of DNA. It generates a signal for certain cancers, including stomach cancer. Researchers want to find a blood-based DNA methylation marker for stomach cancer. Objective: To study plasma DNA methylation as a potential biomarker for detection of stomach cancer. Eligibility: Participants from 2 studies already done in China Design: Researchers will use blood samples from participants in the 2 studies. The blood was collected in 1999/2000. They will use samples from some who developed stomach cancer between those years and 2006. The other samples will be from some who stayed cancer free in that time. Participants already gave written informed consent. Researchers will take DNA from the samples. They will look for methylation.

Sex

All

Minimum age

18 Years

Maximum age

100 Years

* INCLUSION CRITERIA:

Data samples already exist from 2 other IRB approved studies (OH99-C-N031, OH95-C-N027)