Clinical trial · Interventional
To Discuss the Best Mode for Taking Lapatinib Under the Influence of the Diet
NCT03075995CI-TRIAL-00026997unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Food can make a big difference on the bioavailability of lapatinib in breast cancer patients,and fatty food can increase the lapatinib bioavailability.By examine the steady blood drug concentration in the same individual at different treatment mode for lapatinib,emptiness or taken with fatty food,discuss the best mode of taking lapatinib with fatty food.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| hight-fat breakfast | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- lapatinib administered with hight-fat breakfast
- interventionNames
- Other: hight-fat breakfast
Primary outcomes (1)
- measure
- the Best Mode for Takeing Lapatinib
- timeFrame
- 20 days
- description
- by examined the steady state plasa concentration of Lapatinib ,determine which is the best way to take lapatinib,with high-fat breakfast or on an empty stomach
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: 1. Advance breast cancer with her2 positive 2. The patients are ready to use or using lapatinib for tumor treatment, and plans to keep the treatment for at least a month 3. The ECOG score is 0 to 2 4. hemoglobin≥ 9 gm/dL 5. serum albumin concentration is normal 6. ALT / AST / bilirubin\<1.5UL 7. creatinine clearance rate≥ 40 mL/min 8. signed ICF Exclusion Criteria: 1. Pregnancy or Pregnancy 2. Stomach absorption dysfunction 3. Difficulty in taking fatty food 4. Severe heart disease or medical condition
References
Publications (0)
Data not yet available
No reference posted for this study.