Clinical trial · Observational
A Study to Quantify Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
Reduction in Tumour Perfusion for Spine Metastasis Treated With Stereotactic Body Radiotherapy (SBRT)
NCT03072979CI-TRIAL-00026344unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Pre-clinical evidence suggests that radiotherapy reduces tumour-associated vasculature. The investigators will conduct a single-arm prospective study to quantify the reduction in tumour vasculature post-radiotherapy
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Spine Metastasis | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Stereotactic body radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Reduction in vasculature
- timeFrame
- 3 month
- description
- Reduction in vasculature measured by changes on Dynamic Contrast enhanced MRI
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
Show eligibility criteria text
Inclusion Criteria: * Age ≥21 years of age * Proven metastatic disease, excluding haematological and germ cell neoplasms * Life expectancy \>3 months, Eastern Cooperative Oncology group (ECOG) 0-2 Exclusion Criteria: * The patient must not have an allergy to gadolinium contrast that will limit the ability to image the tumour by MRI safely even with the use of premedication * eGFR \< 30 mL/min or if patient is suffering from acute renal insufficiency * Prior radiotherapy to the specified region * Recent surgery to affected spinal levels, or patients requiring immediate surgical intervention * Spinal instability score (SINS) \>12 * Symptomatic cord compression (Bilksy grade 2 or 3), or worsening neurological deficits * Body weight of more than 120kg * Pregnancy
References
Publications (0)
Data not yet available
No reference posted for this study.