Clinical trial · Interventional
Use of Stem Cells Cultured on a Scaffold for the Treatment of Aneurysmal Bone Cysts (ABC)
Autologous Bone Tissue Constructed On Biodegradable Polymer for the Treatment of Aneurysmal Bone Cysts
NCT03066245CI-TRIAL-00039679unknownPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients qualified for this study are those diagnosed with ABCs and failed to be treated with other forms of classical therapies. In which, these patients will be engrafted with biodegradable scaffolds seeded with Mesenchymal Stem Cells (MSCs) supplemented with Platelet lysate.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Aneurysmal Bone Cyst | Aneurysmal Bone Cyst | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MSC-PLGA | Biological | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- MSC-PLGA
- description
- The lesion will be treated with curettage then 1 million of bone marrow derived MSC seeded on 5x5 mm2 PLGA scaffold will be engrafted in the cyst of ABC patient.
- interventionNames
- Biological: MSC-PLGA
Primary outcomes (1)
- measure
- Incidence of Treatment-Emergent Adverse Events [Safety and Tolerability]) as a result of the MSC-PLGA engraftment
- timeFrame
- 3 months
- description
- The safety of the engraftment will be monitored by assessing any adverse event resulting from the engraftment procedure
Secondary outcomes (1)
- measure
- Effectiveness of using PLGA scaffolds seeded with autologous bone marrow MSCs by Radiograph
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 4 Years
- Maximum age
- 28 Years
Show eligibility criteria text
Inclusion Criteria: * Bone cyst diagnosed with MRI, CT-scan, or X-Ray * Intact cyst wall with high risk for fracture * Cysts with minimum diameter of 6mm * Diagnostic test performed on cyst fluid * Diagnosed ABC patients whom treatments with other forms of classical therapies ;such as allograft failed or who are not candidate of autografts * Provided written consent form Exclusion Criteria: * Patients with diagnosis of cancer * Patients enrolled in other clinical trial
References
Publications (0)
Data not yet available
No reference posted for this study.