Clinical trial · Interventional
Comparison of Obturator Nerve Blockade and Neuromuscular Blockade
Comparison of Obturator Nerve Blockade and Neuromuscular Blockade for the Prevention of Adductor Spasm in Patients Undergoing Transurethral Resection of Bladder Tumors.
NCT03063255CI-TRIAL-00050867completedPhase 4Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Patients diagnosed with posterolateral bladder tumors will be invited to participate in the study. Subjects will be randomized to receive an ultrasound-guided obturator block or a neuromuscular blocking agent after the induction of general anesthesia in an attempt to block the obturator reflex during surgery.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer of Bladder | Malignant Bladder Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Neuromuscular block | Drug | — | UNRESOLVED |
| Obturator block | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Obturator block
- description
- Comparing the incidence of adductor spasm in patients undergoing general anesthesia with obturator block.
- interventionNames
- Drug: Obturator block
- type
- ACTIVE_COMPARATOR
- label
- Neuromuscular block
- description
- Comparing the incidence of adductor spasm in patients undergoing general anesthesia with neuromuscular blocking agents.
- interventionNames
- Drug: Neuromuscular block
Primary outcomes (1)
- measure
- Number of Patients With Incidence of Intraoperative Adductor Spasm
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 90 Years
Show eligibility criteria text
Inclusion Criteria: * Patients ≥ 18 years of age * Planned TURBT for unilateral or bilateral posterolateral bladder tumors * Ability to understand and provide informed consent Exclusion Criteria: * Patient refusal or inability to provide informed consent * True allergy, not sensitivity, to local anesthetics * True allergy, not sensitivity, Propofol * True allergy, not sensitivity, general anesthetic agents * Pregnancy * Severe hepatic impairment * Evidence of infection at or near the proposed needle insertion site * Any sensorimotor deficit of the lower extremity, whether acute or chronic * Inability to walk without assistance * Lower extremity joint replacement surgery in the preceding six months
References
Publications (1)
- DERIVEDSoberon JR, Awoniyi CA, Perez MA, Vasilopoulos T, Canales BK. Obturator Nerve Blockade vs. Neuromuscular Blockade for the Prevention of Adductor Spasm in Patients Undergoing Transurethral Resection of Bladder Tumors: A Randomized Controlled Trial. Pain Med. 2021 Jun 4;22(6):1253-1260. doi: 10.1093/pm/pnaa448. PMID 33537703