Zeushield Cytotoxic T Lymphocytes (Z-CTLs) for Relapsed or Refractory Non Small Cell Lung Cancer (NSCLC)

Inclusion Criteria:

* Men or women aged \>18 years old
* Subjects are diagnosed as refractory, recurrent ,metastatic, advanced non-small cell lung cancer by histological and cytological methods including specific lesion-targeted brush biopsy, lavage and fine needle aspiration;
* Have at least one new measurable tumor lesion compared with previous irradiated region
* Tumor tissues samples confirmed as PD-L1 positive
* Expected survival≥12 weeks
* ECOG scored as 0-1 or KPS grading \> 80
* PLT≥100000/mm3
* Hb≥9.0g/dL
* Serum creatinine≤2.5mg/dL，CCR≥50ml/min (renal malfunction defined as CCR\<50ml/min according to Cockroft-Gault formula)
* ALT and AST≤2.5ULN; for liver metastasis，ALT and AST ≤5ULN
* Serum TBiL≤3.0mg/dL, TBiL≤2.5ULN
* PT: INR \< 1.7 or extended PT to normal value \< 4s
* Adequate venous access for apheresis or venous blood collection, and no other contraindication of blood cell separation
* Patients with willingness to be in this study and able to provide informed consent
* Capable of receiving treatment and follow up, included subjects are required to receive treatment in the enrolled centre
* Women of childbearing age are required to take acceptable measures to minimize the possibility of pregnancy during whole session. Women of childbearing age must have negative results of serum or urine tests within 24 hours prior to infusion. Women subjects must not be in lactation;

Exclusion Criteria:

* pregnant women or women in lactation
* active HBV or HCV infection
* HIV/AIDS infection
* active infection
* previously suffered from diseases or concurrent diseases as followed：
* patients confirmed as severe autoimmune diseases in long-term (over 2 months) need of systemic immune inhibitors (steroid) or as immune-mediated symptomatic diseases including ulcerative colitis, Crohn's disease, rheumatoid arthritis, systemic lupus erythematosus (SLE), autoimmune vasculitis (for example, Wegener's granulomatosis)
* subjects with previous diagnosis as motor neurone disease caused by autoimmunity
* subjects previously suffered from toxic epidermal necrolysis (TEN)
* subjects with any mental diseases including dementia, mental status change that may impinge the understanding and performance of informed consent and related questionnaire
* subjects with severe, uncontrollable diseases judged by investigators that may hinder them receiving this treatment
* subjects with previously active malignant tumors including basal or squamous skin cancer, superficial bladder cancer, and in situ breast carcinoma within 5 years who had been completely cured without the need of follow-up treatment are not excluded.
* during ongoing treatment using systemic steroid or steroid inhalants
* subjects with unstable or active peptic ulcer or alimentary tract hemorrhage
* subjects with previous organ transplantation or ready for organ transplantation
* subjects in need of anticoagulant therapy treatment (warfarin or heparin)
* subjects judged by investigators as not appropriate for this study