Clinical trial · Observational
A Study on the Gastrointestinal Disease and Helicobacter Pylori Controlled Long Non-coding RNA
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Helicobacter pylori (H.pylori) is a major human pathogenic bacterium in gastric mucosa which is linked to the development of gastritis, peptic ulcer disease, mucosa-associated lymphoid tissue lymphoma and gastric cancer. However the regulatory mechanism of H.pylori-induced immune response is not clear. Long non-coding RNA (lncRNA) has recently emerged as key post-transcriptional regulators of gene expression, differentiation. The investigators had a preliminary results which THRIL (TNFα and hnRNPL related immunoregulatory lincRNA) and PACER(p50-associated COX-2 extragenic RNA) played a potential role in H.pylori induced inflammatory cascade. However, there wasn't a previous study about expression of THRIL, PACER in a human tissue. Therefore, the investigators aimed to evaluate the expression of THRIL, PACER in patients with gastrointestinal disease according to H.pylori infection.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Duodenal Ulcer | — | UNRESOLVED | — |
| Gastric Ulcer | — | UNRESOLVED | — |
| Helicobacter Pylori Infection | — | UNRESOLVED | — |
| Stomach Cancer | Malignant Gastric Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- Gastric ulcer
- description
- patients who will undergo EGD for gastric ulcer
- label
- Duodenal ulcer
- description
- patients who will undergo EGD for duodenal ulcer
- label
- Stomach cancer
- description
- patients who will undergo EGD for stomach cance
- label
- health individuals
- description
- patients who will undergo screening EGD
Primary outcomes (1)
- measure
- Expression of THRIL, PACER
- timeFrame
- Within 2 weeks after EGD
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 19 Years
Show eligibility criteria text
Inclusion Criteria: 1. Over 19 years old 2. Patients with gastric ulcer 3. Patients with duodenal ulcer 4. Patients with stomach cancer 5. Patients with gastrointestinal discomfort symptoms Exclusion Criteria: 1. Patients who has done helicobacter pylori eradication 2. Patients who has undergone gastrectomy 3. Patients who has undergone endoscopic submucosal dissection 4. Patients with active upper gastrointestinal bleeding
References
Publications (0)
Data not yet available