Study of Apatinib in Advanced Hepatocellular Carcinoma(HCC)

Inclusion Criteria:

1. Before doing any research steps, the patient's informed consent must be obtained first.
2. The diagnosis of HCC: histologic diagnosis or Alpha fetoprotein (AFP) with two kinds of imaging diagnosis.
3. Patients of Barcelona stage(BCLC) C with first-line treatment failure or non tolerance to sorafenib.
4. Ages of 18 to 75 years old.
5. Child-Pugh score between 5-7 points, patients of Child-Pugh 7 points should be without ascites.
6. Eastern Cooperative Oncology Group performance score (ECOG PS) is 0-1 point.
7. Adequate organ function meeting the following:

   Hemoglobin(HBG)≧9.0g/dl Neutrophil count(ANC) ≧1,500/mm3 Platelet count(PLT)≧50,000/ul Total bilirubin (TBIL)\< 2mg/dL (3mg/dL, Child-Pugh B) Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST) \< 5×ULN (upper limit of normal) ALP (alkaline phosphatase ) \< 4×ULN PT (prothrombin time) \>50% or PT-INR\<2.3, \<6 seconds or greater than that of the control
8. For patients taking warfarin, at least once a week to a close monitoring of the patients, until, according to the standard of treatment, at every time of medication, the subjects' INR measurements has been stable
9. SCr (serum creatinine) \<1.5×ULN
10. For pregnant women, the results of serum pregnancy tests must be negative within 14 days before initiation of treatment.
11. All men and women who participated in the study had to take reliable contraceptive measures within the trial and two weeks of after the trial.

Exclusion Criteria:

1. Patients of Child-Pugh 7 has serious uncontrolled ascites.
2. Patients with serious cardiovascular disease.
3. Patients with high blood pressure of unable to control.
4. Patients has the history of HIV (human immunodeficiency virus) infection.
5. Active clinical severe infection (\> 2, NCI-CTCAE version 3).
6. Need to drug treatment of patients with epilepsy (such as steroid or antiepileptic drugs)
7. Has a history of allogeneic organ transplantation.
8. Patients with a history of physical signs or have a bleeding.
9. Patients undergoing renal dialysis.
10. Metastatic liver cancer.
11. Patients with uncontrollable ascites.
12. Patients with encephalopathy.
13. Patients has history of gastrointestinal bleeding period of 30 days before join the study.
14. Patients with a history of esophagus varicosity burst hemorrhage, then not effective treatment or therapy to prevent recurrence of bleeding.