Clinical trial · Interventional
Hysterectomy and OPPortunistic SAlpingectomy
Hysterectomy and Opportunistic Salpingectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
HOPPSA is a register based randomized controlled trial (R-RCT), with the objective to examine if opportunistic salpingectomy compared with no salpingectomy, at the time of hysterectomy for a benign reason * has no increased risk of complications * has no negative side effects on ovarian function and subsequent cardiovascular disease or incidence of fractures * implies reduced risk of subsequent ovarian cancer Randomization and follow-up will be conducted within national registers.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Complication | — | UNRESOLVED | — |
| Ovarian Cancer | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Salpingectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Salpingectomy
- description
- Concomitant salpingectomy at the time of hysterectomy for a benign reason
- interventionNames
- Procedure: Salpingectomy
- type
- NO_INTERVENTION
- label
- No salpingectomy
- description
- No salpingectomy at the time of hysterectomy for a benign reason
Primary outcomes (3)
- measure
- Surgical complication - short term primary outcome
- timeFrame
- Eight weeks post-operative
- description
- Dichotomous outcome, retrieved from any of two sources in the GynOp register: specified question on complications and the Clavien-Dindo classification
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 54 Years
Show eligibility criteria text
Inclusion Criteria: * Planned hysterectomy for a benign reason * Age \< 55 years at randomization * Willing to be randomized * Vaginal route may be included if the surgeon is confident with performing vaginal salpingectomy. Exclusion Criteria: * Previous bilateral oophorectomy and/or salpingectomy * Planned oophorectomy and/or salpingectomy (for reasons such as already diagnosed adnexal tumor, known carrier of the breast cancer susceptibility gene (BRCA) 1/2 mutation or Lynch syndrome (hereditary nonpolyposis colorectal cancer)) * Non-understanding of the oral or written study information
References
Publications (2)
- DERIVEDDarelius A, Idahl A, Sundfeldt K, Strandell A. Effect of opportunistic salpingectomy at hysterectomy on anti-Mullerian hormone: A substudy of a randomized trial. Acta Obstet Gynecol Scand. 2026 Aug;105(8):1480-1489. doi: 10.1111/aogs.70247. Epub 2026 May 19. PMID 42157582
- DERIVEDIdahl A, Liv P, Darelius A, Collins E, Sundfeldt K, Palsson M, Strandell A. HOPPSA update: changes in the study protocol of Hysterectomy and OPPortunistic SAlpingectomy, a registry-based randomized controlled trial. Trials. 2023 Mar 24;24(1):222. doi: 10.1186/s13063-023-07244-w. PMID 36959664