Clinical trial · Interventional
Intracorporeal or Extracorporeal Anastomosis After Laparoscopic Right Colectomy.
Intracorporeal or Extracorporeal Ileocolic Anastomosis After Laparoscopic Right Colectomy.
NCT03045107CI-TRIAL-00027358unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
During the last few years, the laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA) has been proposed as an alternative to laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA) for the treatment of right colon tumors. However, the level of evidence coming from the currently available literature is low, based on the results of a few small and heterogeneous retrospective non-randomized studies. A randomised controlled trial is warranted to challenge these two procedures. The aim of this randomized controlled trial is to assess the outcomes after IIA or EIA after laparoscopic right colectomy for right colon tumors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomosis | — | UNRESOLVED | — |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA) | Procedure | — | UNRESOLVED |
| Laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intracorporeal ileocolic anastomosis (IIA)
- description
- After complete right colon mobilization and ileocolic and right colic vessels ligation, the proximal transverse colon and the terminal ileum are transected and a side-to-side anastomosis is fashioned with a laparoscopic stapler.
- interventionNames
- Procedure: Laparoscopic right colectomy with intracorporeal ileocolic anastomosis (IIA)
- type
- ACTIVE_COMPARATOR
- label
- Extracorporeal ileocolic anastomosis
- description
- After complete right colon mobilization and ileocolic and right colic vessels ligation, the terminal ileum, right colon, and proximal transverse colon are exteriorized for bowel division through a small midline skin incision in the upper abdomen. Then, a primary ileocolic side-to-side handsewn or mechanical anastomosis is fashioned extracorporeally.
- interventionNames
- Procedure: Laparoscopic right colectomy with extracorporeal ileocolic anastomosis (EIA)
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient diagnosed with a solitary benign or malignant neoplasm localized in the right colon * Patients aged 18 years or older * Patients who give written informed consent Exclusion Criteria: * acute intestinal obstruction * colon perforation; * liver and/or lung metastases; * multiple primary colonic tumors; * scheduled need for synchronous intra-abdominal surgery; * preoperative evidence of invasion of adjacent structures, as assessed by CT or ultrasonography; * previous ipsilateral colon surgery.
References
Publications (11)
- RESULTHellan M, Anderson C, Pigazzi A. Extracorporeal versus intracorporeal anastomosis for laparoscopic right hemicolectomy. JSLS. 2009 Jul-Sep;13(3):312-7. PMID 19793468
- RESULTFabozzi M, Allieta R, Brachet Contul R, Grivon M, Millo P, Lale-Murix E, Nardi M Jr. Comparison of short- and medium-term results between laparoscopically assisted and totally laparoscopic right hemicolectomy: a case-control study. Surg Endosc. 2010 Sep;24(9):2085-91. doi: 10.1007/s00464-010-0902-8. Epub 2010 Feb 21. PMID 20174945
- RESULTGrams J, Tong W, Greenstein AJ, Salky B. Comparison of intracorporeal versus extracorporeal anastomosis in laparoscopic-assisted hemicolectomy. Surg Endosc. 2010 Aug;24(8):1886-91. doi: 10.1007/s00464-009-0865-9. Epub 2010 Jan 29. PMID 20112118
- RESULTChaves JA, Idoate CP, Fons JB, Oliver MB, Rodriguez NP, Delgado AB, Lizoain JL. [A case-control study of extracorporeal versus intracorporeal anastomosis in patients subjected to right laparoscopic hemicolectomy]. Cir Esp. 2011 Jan;89(1):24-30. doi: 10.1016/j.ciresp.2010.10.003. Epub 2010 Dec 19. Spanish. PMID 21176829
- RESULTRoscio F, Bertoglio C, De Luca A, Frattini P, Scandroglio I. Totally laparoscopic versus laparoscopic assisted right colectomy for cancer. Int J Surg. 2012;10(6):290-5. doi: 10.1016/j.ijsu.2012.04.020. Epub 2012 May 4. PMID 22564829
- RESULTScatizzi M, Kroning KC, Borrelli A, Andan G, Lenzi E, Feroci F. Extracorporeal versus intracorporeal anastomosis after laparoscopic right colectomy for cancer: a case-control study. World J Surg. 2010 Dec;34(12):2902-8. doi: 10.1007/s00268-010-0743-6. PMID 20703468
- RESULTMilone M, Elmore U, Di Salvo E, Delrio P, Bucci L, Ferulano GP, Napolitano C, Angiolini MR, Bracale U, Clemente M, D'ambra M, Luglio G, Musella M, Pace U, Rosati R, Milone F. Intracorporeal versus extracorporeal anastomosis. Results from a multicentre comparative study on 512 right-sided colorectal cancers. Surg Endosc. 2015 Aug;29(8):2314-20. doi: 10.1007/s00464-014-3950-7. Epub 2014 Nov 21.