Clinical trial · Observational
Congenital Lung Anomalies (CLA) Swiss Database
Follow up of Congenital Lung Anomalies (CLA) With Antenatal Diagnosis - a Swiss Multicentric Database
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Congenital lung anomalies include different pathologies such as congenital cystic adenomatoid malformation, pulmonary sequestration, bronchial atresia, emphysema, bronchogenic cyst. They concern less than 1/10000 births and their physiopathological origin is still poorly understood. The main goal of this project is to pool the cases from different swiss centers on a prospective cohort study, first to increase knowledge of clinical and radiological evolution and their correlation with histological data, and second to analyse the pathological embryological mechanism underlying these malformations.
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acinar Dysplasia | — | UNRESOLVED | — |
| Bronchogenic Cancer | — | UNRESOLVED | — |
| Congenital Lung Cyst | — | UNRESOLVED | — |
| Congenital Lung Malformation | — | UNRESOLVED | — |
| Pleuropulmonary Blastoma | Pleuropulmonary Blastoma | ONTOLOGY_EXACT | 0.98 |
| Sequestrum | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Malformations resection | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Patient with CLA with surgery
- interventionNames
- Procedure: Malformations resection
- label
- Patient with CLA without surgery
Primary outcomes (7)
- measure
- Change in clinical of patients with CLA between different time point
- timeFrame
- Birth, 1 month of life, 4 months of life, 9-18 months of life, 6 months post surgery, 1 year post surgery, 7 years old, 10 years old, 12 years old
- description
- Clinical measurements: size (cm), weight (kg), saturation (%)
- measure
- Analysis of CLA physiopathology
- timeFrame
- samples collected during surgery
- description
- Analysis of growth factors, transcription factors and extracellular components implicated in CLA genesis by immunohistochemistry, transcriptomic and proteomic methods
Eligibility
Eligibility (as posted)
- Sex
- All
- Maximum age
- 16 Years
Show eligibility criteria text
Inclusion Criteria: * All patients diagnosed with congenital lung anomalies Exclusion Criteria: * None
References
Publications (0)
Data not yet available