Clinical trial · Observational
Mapping Sound Propagation Through the Human Lung for Better Diagnosis
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): COVID-19
Summary
Brief summary (as posted)
This study investigates the propagation of sound from a source in the chest to the chest wall. The methodology of the study will be to place a sound source at a known location in the chest and measure the acoustic response on the posterior chest wall with an acoustic sensor array. The sound source will be created by playing sound down the working channel of a bronchoscope and located anatomically using direct imaging. Subjects will be selected for the study by asking patients undergoing a bronchoscopy procedure whether they would be willing to take part in the experiment in addition to their standard procedure. Procedures will take place in the Bronchoscopy Unit at Addenbrooke's hospital in Cambridge. The Unit runs regional speciality clinics in severe chronic obstructive pulmonary disease, asthma, lung cancer, bronchomalacia and interstitial lung disease and has a nationally significant interventional bronchoscopy service. A subsidiary part of the study (Part A) will collect sound recordings from healthy volunteers and patients with common respiratory diseases using the same acoustic sensor array. This is to create a database of lung sounds and quantify inter-subject variability. The study will last approximately 30 months.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Asthma | — | UNRESOLVED | — |
| Bronchomalacia | — | UNRESOLVED | — |
| Lung Diseases, Interstitial | — | UNRESOLVED | — |
| Lung Neoplasms | Lung Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Pulmonary Disease, Chronic Obstructive | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lung sound recording | Other | — | UNRESOLVED |
| Lung sound transmission measurement | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- Part A(i) Healthy Volunteers
- description
- 50 healthy volunteers. Intervention: Lung sound recording for part A(i) of the study.
- interventionNames
- Other: Lung sound recording
- label
- Part A(ii) Patients
- description
- 100 patients with wheezing and/or crackles due to respiratory disease. Intervention: Lung sound recording for part A(ii) of the study.
- interventionNames
- Other: Lung sound recording
- label
- Part B(i) 'normal' lung structure
- description
- 25 patients who are scheduled to have a Bronchoscopy as part of their standard care and are identified by a medical professional as having a 'normal' lung structure. Intervention: Lung sound transmission measurement for part B(i) of the study.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Participant is willing and able to give informed consent for participation in the study. * Male of Female, aged 18 years or above. * Part A(i) Healthy volunteer with no history of smoking, recreational drug use or respiratory disease. * Part A(ii) Patient admitted to Addenbrooke's with a pulmonary disease resulting in crackles and/or wheezes (as diagnosed by a qualified medical practitioner). * Part B Patient admitted to Addenbrooke's hospital for a bronchoscopy procedure. * Part B Appropriate recent imaging available: chest CT within 3 months. * Part B(i) Lung structure deemed 'normal' by pulmonary physician based on CT scan and medical history. * Part B(i) Lung structure deemed 'abnormal' by pulmonary physician based on CT scan and medical history. Exclusion Criteria: * Informed consent is not given. * Subject is under 18 years old. * WHO performance status \>2. * Subject is pregnant. * Subject is unable to understand English. * Part A(i) History of smoking, recreational drug use or respiratory disease. * Part A(ii) Condition judged to have no effect on breathing sounds. Patient with crackle or wheeze when quota for crackle or wheeze patients respectively is fulfilled. * Part B Risk associated with prolonging bronchoscopy procedure judged to be too high by medical professional. * Part B Appropriate recent imaging (chest CT within 3 months) not available.
References
Publications (0)
Data not yet available