Clinical trial · Interventional
Impact of Proximal Colon Retroflexion in Colorectal Cancer Screening Programme
Impact of Proximal Colon Retroflexion in Colorectal Cancer Screening Programme: Randomized Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colorectal cancer (CRC) is the most common tumor and the second leading cause of death in the Western world. The decrease in incidence and mortality by CRC in the population undergoing screening has been observed. Colonoscopy is the recommended method for detecting tumors in early stages, as well as identifying and resecting adenomatous polyps, which are the precursor lesions of most CRCs. Colonoscopy should be of high quality to decrease incidence and mortality by CRC and avoid interval cancer. The literature shows that colonoscopy does not prevent right colon lesions in the same way as the left colon lesions, with most of the interval cancers located in the right colon. Studies published so far show an increase in the adenomas detection rate (ADT) in the right colon in the second visualization of this segment and an increase between 2 and 10% if this second examination is performed with the proximal retroflexion maneuver.Retroflexion is a safe maneuver in expert endoscopists. The aim of our study is to evaluate the ADT in the right colon by means of a second visualization by performing proximal retroflexion or second frontal visualization at random in the CCR screening population.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenoma Detection Rate | — | UNRESOLVED | — |
| Colorectal Neoplasms | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Frontal view | Procedure | — | UNRESOLVED |
| Proximal retroflexion | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- proximal retroflexion
- description
- Procedure: The endoscopy explore right colon with frontal view and a second look with proximal retroflexion
- interventionNames
- Procedure: Proximal retroflexion
- Procedure: Frontal view
- type
- ACTIVE_COMPARATOR
- label
- frontal view of right colon
- description
- Procedure: The endoscopy explore right colon with frontal view and frontal view
- interventionNames
- Procedure: Frontal view
Primary outcomes (1)
- measure
- Proximal retroflexion improve adenoma detection rate in colorectal cancer screening
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 69 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects participating in the Colorectal cancer Screening program with faecal immunological test \> 100ng / ml. * Ages between 50-69 years. * Adequate preparation according to the Boston scale: in right colon (score\> 2 in this section) * Informed consent. Exclusion Criteria: * Refusal to give informed consent. * Subjects with elevated colorectal cancer risk due to family history or inherited diseases of polyposis or inflammatory bowel disease * Symptomatic subjects. * Diverticulitis, inflammatory bowel disease or colonic stenosis during the exploration * Inadequate preparation according to Boston cleanliness scale (score ≤ 2 in right colon)
References
Publications (0)
Data not yet available