Clinical trial · Interventional
Conservative Versus Liberal Oxygenation Targets in Critically Ill Children
A Randomised Pilot Multiple Centre Trial of Conservative Versus Liberal Oxygenation Targets in Critically Ill Children
NCT03040570CI-TRIAL-00031776Oxy-PICUcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
A feasibility study to determine if it is possible to perform a safe, adequately powered, and affordable multi-centre study in critically ill children comparing current practice of liberal targets for systemic oxygen levels with more conservative targets.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Critical Care | — | UNRESOLVED | — |
| Hypoxia | — | UNRESOLVED | — |
| Pediatric ALL | Childhood Acute Lymphoblastic Leukemia | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conservative oxygenation target | Procedure | — | UNRESOLVED |
| Liberal oxygenation target | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Conservative oxygenation target
- description
- Children in the conservative oxygenation target group receive treatment targeting oxygen saturation values of 88-92%.
- interventionNames
- Procedure: Conservative oxygenation target
- type
- ACTIVE_COMPARATOR
- label
- Liberal oxygenation target
- description
- Children in the liberal oxygenation target group receive treatment targeting oxygen saturation values of \>94%.
- interventionNames
- Procedure: Liberal oxygenation target
Primary outcomes (1)
- measure
- Number of eligible patients recruited per site per month
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 39 Weeks
- Maximum age
- 15 Years
Show eligibility criteria text
Inclusion Criteria: * less than 16 years and \> 38 weeks corrected gestational age * receiving supplemental oxygen for abnormal gas exchange * emergency admission accepted to a participating paediatric intensive care unit (PICU) requiring mechanical ventilation within first 6 hours of face-to-face contact with PICU staff or transport team Exclusion Criteria: * recruited to Oxy-PICU in a previous admission * brain pathology/injury as a primary reason for admission (e.g traumatic brain injury, post-cardiac arrest, stroke, convulsive status epilepticus without aspiration) * known pulmonary hypertension * known or suspected sickle cell disease * known or suspected uncorrected congenital cardiac disease * End-of-life care plan in place with limitation of resuscitation * not expected to survive PICU admission * receiving long-term mechanical ventilation prior to this admission (non-invasive ventilation or invasive ventilation)
References
Publications (3)
- DERIVEDJones GAL, Eaton S, Orford M, Ray S, Wiley D, Ramnarayan P, Inwald D, Grocott MPW, Griksaitis M, Pappachan J, O'Neill L, Mouncey PR, Harrison DA, Rowan KM, Peters MJ; Oxy-PICU Investigators of the Paediatric Critical Care Society Study Group (PCCS-SG). Randomization to a Liberal Versus Conservative Oxygenation Target: Redox Responses in Critically Ill Children. Pediatr Crit Care Med. 2023 Mar 1;24(3):e137-e146. doi: 10.1097/PCC.0000000000003175. Epub 2023 Jan 19. PMID 36728001
- DERIVEDPeters MJ, Jones GAL, Wiley D, Wulff J, Ramnarayan P, Ray S, Inwald D, Grocott M, Griksaitis M, Pappachan J, O'Neill L, Eaton S, Mouncey PR, Harrison DA, Rowan KM; Oxy-PICU Investigators for the Paediatric Intensive Care Society Study Group (PICS-SG). Conservative versus liberal oxygenation targets in critically ill children: the randomised multiple-centre pilot Oxy-PICU trial. Intensive Care Med. 2018 Aug;44(8):1240-1248. doi: 10.1007/s00134-018-5232-7. Epub 2018 Jun 4. PMID 29868973
- DERIVEDJones GAL, Ramnarayan P, Raman S, Inwald D, Grocott MPW, Eaton S, Ray S, Griksaitis MJ, Pappachan J, Wiley D, Mouncey PR, Wulff J, Harrison DA, Rowan KM, Peters MJ; Oxy-PICU Investigators for thePaediatric Intensive Care Society-Study Group (PICS-SG). Protocol for a randomised pilot multiple centre trial of conservative versus liberal oxygenation targets in critically ill children (Oxy-PICU). BMJ Open. 2017 Dec 14;7(12):e019253. doi: 10.1136/bmjopen-2017-019253. PMID 29247112