Clinical trial · Interventional
General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial
General Anesthetics in CAncer REsection Surgery (GA-CARES) Trial: Pragmatic Randomized Trial of Propofol vs Volatile Inhalational Anesthesia
NCT03034096CI-TRIAL-00089266GA-CAREScompletedPhase 4ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a large pragmatic multicenter trial comparing maintenance of general anesthesia with total intravenous anesthesia using propofol versus volatile agent (sevoflurane, isoflurane, or desflurane) during cancer surgery. The primary endpoint is all-cause mortality.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia, General | — | UNRESOLVED | — |
| Surgical Oncology | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Propofol | Drug | — | UNRESOLVED |
| Volatile Agent | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Propofol infusion
- description
- Maintenance of general anesthesia with propofol infusion
- interventionNames
- Drug: Propofol
- type
- EXPERIMENTAL
- label
- Volatile agent
- description
- Maintenance of general anesthesia with volatile agent (sevoflurane, desflurane, or isoflurane)
- interventionNames
- Drug: Volatile Agent
Primary outcomes (1)
- measure
- All-cause mortality
- timeFrame
- 2 year minimum
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with known or suspected cancer and scheduled to undergo any of the following oncologic surgical procedures: * Lobectomy or pneumonectomy * Esophagectomy * Radical (total) cystectomy * Pancreatectomy * Partial hepatectomy * Hyperthermic intraperitoneal chemotherapy (HIPEC) * Gastrectomy (subtotal or total) * Cholecystectomy or bile duct resection Exclusion Criteria: * Age less than 18 years * American Society of Anesthesiologist Class 5 * Projected life expectancy less than 30 days * Known or suspected hypersensitivity to either propofol, e.g. egg or soy allergy, or volatile general anesthetic agents * Known or suspected history of malignant hyperthermia
References
Publications (2)
- DERIVEDBennett-Guerrero E, Romeiser JL, DeMaria S, Nadler JW, Quinn TD, Ponnappan SK, Wang R, Gloff MS, Lee KJ, Levin MA, Sroka RD, Stanley SL, Wang D, Sasson AR; GA-CARES Trial Group. Anesthesia Type during Cancer Surgery: Results of the GA-CARES Randomized, Multicenter Trial. Anesthesiology. 2026 Jan 1;144(1):51-62. doi: 10.1097/ALN.0000000000005769. Epub 2025 Dec 9. PMID 41363871
- DERIVEDBennett-Guerrero E, Romeiser JL, DeMaria S, Nadler JW, Quinn TD, Ponnappan SK, Yang J, Sasson AR. General Anesthetics in CAncer REsection Surgery (GA-CARES) randomized multicenter trial of propofol vs volatile inhalational anesthesia: protocol description. Perioper Med (Lond). 2023 Jan 11;12(1):2. doi: 10.1186/s13741-022-00290-z. PMID 36631831