Clinical trial · Observational
Diagnostic Accuracy of Circulating Tumor Cells (CTCs) and Onco-exosome Quantification in the Diagnosis of Pancreatic Cancer - PANC-CTC
NCT03032913CI-TRIAL-00032459PANC-CTCcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The proposal aims at determining whether liquid biopsy approaches are valid in the diagnosis of pancreatic cancer. Step1 will test 3 CTC isolation methods and analyse by flow cytometry the presence of onco-exosomes in the culture media of pancreatic cell lines. Step 2 will examine the diagnostic accuracy of these blood tumor elements for the diagnosis of cancer of patients with PDAC suspicion or recent diagnosis and their value for disease monitoring.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pancreatic Ductal Adenocarcinoma (PDAC) | Pancreatic Ductal Adenocarcinoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood samples | Procedure | — | UNRESOLVED |
| Portal vein blood sample | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Pancreatic ductal adenocarcinoma patients
- description
- Patients with recent diagnosis of pancreatic ductal adenocarcinoma (PDAC) or with strong suspicion PDAC
- interventionNames
- Procedure: Blood samples
- Procedure: Portal vein blood sample
- label
- Non-cancer patients
- description
- Patients with no Cancer
- interventionNames
- Procedure: Blood samples
Primary outcomes (2)
- measure
- Step 1: sensitivity of CTC detection with 3 methods in cell spiking experiments
- timeFrame
- 6 months
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patient with informed consent * Patient with health care coverage * Group of PDAC patients: Patient with resectable lesion with suspicion or recent diagnosis of PDAC recruited in the surgery department * Group of non-cancer patients: Patients in the surgery department without cancer lesion, Patients with intestine inflammatory disease, Patients with gastric bypass or sleeve gastrectomy procedure Exclusion Criteria: * Patients \<18 or under tutelage * Patient with recent chemotherapy or radiotherapy * Pregnant or lactating woman * Patient with negative or non-informative biopsy * Patient with technically unserectable disease
References
Publications (0)
Data not yet available
No reference posted for this study.