Clinical trial · Observational
Comparison or Rose Bengal and Toluidine Blue Staining for Lesion Detection Efficacy
Efficacy of Rose Bengal in Comparison With Toluidine Blue in Detection of Premalignant Lesions: a Preliminary Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Abstract Objective: To study the diagnostic efficiency of Rose Bengal with Toluidine blue in detecting the biopsy sites and thus establish an accurate diagnosis in oral premalignant lesions. Materials and method: In our study 27 patients with 41 lesions were included. Since one patient had not quit the habit in the two weeks following initial examination and another lesion disappeared in the waiting period, 2 patients (3 lesions) were not included in the study. Out of 38 lesions diagnosed based on clinical criteria, 32 were leukoplakia, 5 lichen planus and 1 SCC. After initial examination they were subjected to Rose Bengal and Toluidine blue stain. If stained positive they were subjected to biopsy.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Oral Leukoplakia | — | UNRESOLVED | — |
| Oral Lichen Planus | — | UNRESOLVED | — |
| Premalignant Lesion | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Biopsy | Procedure | — | UNRESOLVED |
| Rose Bengal | Diagnostic Test | — | UNRESOLVED |
| toluidine blue | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Rose Bengal positive lesion and biopsy
- description
- Lesions that were stained positive with rose bengal were biopsied and assessed for dysplasia
- interventionNames
- Procedure: Biopsy
- Diagnostic Test: Rose Bengal
- label
- Toluidine blue positive lesion and biopsy
- description
- Lesions that were stained positive with toluidine blue were biopsied and assessed for dysplasia
- interventionNames
- Procedure: Biopsy
- Diagnostic Test: toluidine blue
Primary outcomes (2)
- measure
- Number and Percentage of Lesions That Were Stained Positive
- timeFrame
- 2 weeks
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with clinically diagnosed oral premalignant lesions (oral leukoplakia and oral lichen planus). Exclusion Criteria: * Patients with OSMF * bleeding disorders and * other systemic diseases
References
Publications (0)
Data not yet available