Clinical trial · Interventional
Simulated-altitude to Optimize Aerobic Exercise Among Breast Cancer Survivors With Limited Mobility
Simulated-Altitude as an Adjunct to Optimize Aerobic Exercise in Obese Breast Cancer Survivors With Limited Ambulatory Function: Pilot Randomized Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study will evaluate the utility of hypoxic exercise training to improve cardiovascular and metabolic health among obese breast cancer survivors. While participants exercise, a lower fraction of inspired oxygen will be used to simulate a higher altitude. This approach removes the mechanical strain needed to sustain moderate-to-vigorous exercise intensity which is believed to support exercise tolerance. Participants are randomized to either the treatment (walking+simulated-altitude) or control (walking under normoxic conditions).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Obesity | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Walking (control) | Behavioral | — | UNRESOLVED |
| Walking+simulated-altitude | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Walking+simulated-altitude
- description
- 8-week exercise training program that involves 3 supervised, treadmill walking sessions each week with 16% oxygen, which will be administered through an exercise mask.
- interventionNames
- Other: Walking+simulated-altitude
- type
- ACTIVE_COMPARATOR
- label
- Walking (control)
- description
- 8-week exercise training program that involves 3 supervised, treadmill walking session each week.
- interventionNames
- Behavioral: Walking (control)
Primary outcomes (3)
- measure
- Determine the feasibility of an 8 week exercise intervention comparing walking+simulated-altitude to walking (control) based on retention.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Physician's medical clearance for participation 2. English-speaking women 3. 18-70 years of age with a history of Stage 0-III breast cancer 4. Preferred walking speed of less than 2.9 mph as measured by a timed 10 meter walk test (to be performed on-site after consent during preliminary screening) "OR" the inability to complete a 6-minute walk without stopping (to be performed on-site after consent during preliminary screening) 5. Body mass index between 30-45 kg/m2 6. ≥1 year post-treatment and not currently receiving or planning to receive chemo/radiation therapies 7. Not participating in a structured exercise routine 8. In the previous 6 months, not engaging in (on average) ≥60 minutes of moderate or ≥30 minutes of vigorous physical activity per week. Exclusion Criteria: 1. Males 2. Dementia 3. Medical, psychological, and/or social characteristics that may interfere with the ability to fully participate in the proposed study activities/assessments (e.g., psychosis, schizophrenia) 4. Contraindication to participate in regular exercise training 5. Unwilling to complete prescribed exercise 6. Inability to walk 7. Pregnant 8. Resting oxygen saturation via pulse oximetry below 90% 9. Using home oxygen therapy
References
Publications (0)
Data not yet available