Clinical trial · Interventional
Yttrium Y-90 Radioembolization in Treating Patients With Metastatic Liver Cancer
Feasibility of Single Session In-Room Yttrium-90 Radioembolization Diagnostic Angiography and Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 17, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260917-000001
Summary
Brief summary (as posted)
This clinical trial studies the side effects and best way to perform yttrium Y-90 radioembolization in treating patients with liver cancer that has spread to other places in the body (metastatic). Yttrium Y-90 radioembolization is a therapy that injects radioactive microspheres directly into an artery that feeds liver tumors to cut off their blood supply. Performing yttrium Y-90 radioembolization in a single session may make treatment faster, minimize patient travel, and decrease the overall cost of the procedure.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastatic Liver Carcinoma | Liver Carcinoma | CURATED_BROADER | 0.78 |
| Stage IVA Liver Cancer | Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
| Stage IVB Liver Cancer | Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
| Stage IV Liver Cancer | Malignant Liver Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Angiography | Procedure | — | UNRESOLVED |
| Computed Tomography | Procedure | — | UNRESOLVED |
| Planar Imaging | Procedure | — | UNRESOLVED |
| Radioembolization | Radiation | — | UNRESOLVED |
| Single Photon Emission Computed Tomography | Procedure | — | UNRESOLVED |
| Technetium Tc-99m Albumin Aggregated | Radiation | — | UNRESOLVED |
| Yttrium Y 90 Resin Microspheres | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Treatment (angiography, yttrium Y-90 radioembolization)
- description
- The first 2 patients enrolled receive standard of care diagnostic and treatment during 2 visits for approximately 6 hours each within 2-4 weeks. During the first visit, patients undergo diagnostic angiography with embolization of potential hepatoenteric collaterals, receive technetium Tc-99m albumin aggregated as a surrogate to the therapy microspheres via catheter, and undergo planar imaging. During the second visit, patients undergo a second angiography and receive yttrium Y 90 resin microspheres via arterial microcatheter. Patients then undergo single-photon emission computed tomography-computed tomography (SPECT-CT) Bremsstrahlung imaging. All subsequent patients enrolled undergo the same previously described diagnostic and treatment during 1 visit over about 8 hours.
- interventionNames
- Procedure: Angiography
- Procedure: Computed Tomography
- Procedure: Planar Imaging
- Radiation: Radioembolization
- Procedure: Single Photon Emission Computed Tomography
- Radiation: Technetium Tc-99m Albumin Aggregated
- Other: Yttrium Y 90 Resin Microspheres
Primary outcomes (2)
- measure
- Success of same day yttrium Y-90 radioembolization planning and treatment angiography
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * The ability to understand and sign informed consent * Any candidate eligible for standard of care Y90 radioembolization for treatment of their primary or metastatic liver tumors Exclusion Criteria: * Patients with greater than 50% liver tumor burden
References
Publications (0)
Data not yet available