A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects

Inclusion Criteria:

* Subjects with benign (WHO grade I) centrally located intracranial tumors which require clinical intervention and are known to carry minimal hemorrhage risk
* Minimum head circumference will be 49cm
* Skull Density Ratio (SDR) should be ≥0.35
* Subjects should be on a stable dose of all condition-related medications for 30 days prior to study entry as determine by medical records
* Subjects and/or parent(s)/legal representative can provide accurate seizure diary log for the 30 days prior to FUS treatment and for the duration of the study

Exclusion Criteria:

* Subjects with unstable cardiac status that would increase anesthetic risk including
* Subjects exhibiting any behavior(s) consistent with ethanol or substance abuse as defined by the criteria outlined in the DSM-IV
* Subjects who are taking human growth hormone (hGH), also known as somatotropin
* Subjects with standard contraindications for MR imaging such as non-MRI compatible implanted metallic devices including vagus nerve stimulator, responsive neurostimulator, cardiac pacemakers, non-metallic shunts, size limitations, etc.
* Known intolerance or allergies to the MRI contrast agent (e.g. Gadolinium or Magnevist) or sedative medications
* Severely impaired renal function (estimated glomerular filtration rate \<70% of normal GFR for age) or receiving dialysis
* Any history of clinically significant abnormal bleeding and/or coagulopathy
* Receiving anticoagulant (e.g. warfarin) or antiplatelet (e.g. aspirin, NSAIDs) therapy within one week of focused ultrasound procedure or drugs known to increase risk or hemorrhage (e.g. Avastin) within one month of focused ultrasound procedure; or, unable or unwilling to stop anticoagulant for the purpose of focused ultrasound procedure
* Use of valproate derivatives for seizure control within the preceding 2 weeks
* Known or suspected acute, active, or uncontrolled infection
* History of postnatal stroke or intracranial hemorrhage within 6 months
* Clinical suspicion of increased intracranial pressure (as evidenced by symptoms of obstruction: headache, nausea, vomiting, lethargy, and papilledema)
* Have participated in another interventional trial in the last 30 days
* History of immunocompromise, including subject who is HIV positive with incomplete viral suppression
* Known life-threatening systemic disease
* Subjects with suicidal ideation or previous suicide attempt within the past year
* Subjects with malignant brain tumors, or the presence of any ambiguous clinical features that could imply a malignant potential to the tumor, or for which a biopsy is necessary
* Subjects for whom histopathology is important for ongoing management
* Female subjects who are pregnant, breast feeding or planning to become pregnant during the study or are unwilling to practice birth control during participation in the study, if of child-bearing age