Clinical trial · Observational
Biomarkers as Predictors of Suicidal Risk in Adolescents
Peripheral Neuroinflammatory Predictors of Suicidal Risk at Time of Inpatient Discharge in Adolescents
NCT03014518CI-TRIAL-00052737completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk. We will utilize blood biomarker measurement and clinical risk factor scales to develop a tool to identify adolescents at risk for suicide earlier, which will allow clinicians to prescribe timely treatment and prevent suicide.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Suicidal Ideation | — | UNRESOLVED | — |
| Suicidal Intention | — | UNRESOLVED | — |
| Suicide | — | UNRESOLVED | — |
| Suicide, Attempted | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Clinical assessments and blood samples; follow-up for 12 mos | Other | — | UNRESOLVED |
| Clinical assessments and blood samples; no 12mo follow-up | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Suicide Attempt Study Group
- description
- Adolescents admitted to the Cleveland Clinic inpatient child and adolescent psychiatry unit after suicide attempt. Clinical assessments and blood samples; follow-up for 12 mos.
- interventionNames
- Other: Clinical assessments and blood samples; follow-up for 12 mos
- label
- Healthy Control Group
- description
- Healthy adolescents with no history of suicide attempt. Clinical assessments and blood samples; no 12mo follow-up.
- interventionNames
- Other: Clinical assessments and blood samples; no 12mo follow-up
Primary outcomes (2)
- measure
- Relation between levels of peripheral inflammatory markers and suicide attempt
- timeFrame
- baseline
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Suicide Attempt Study Group: * 12-18 years of age * admitted to the Cleveland Clinic inpatient child and adolescent psychiatry unit after suicidal ideations or a suicide attempt Healthy Control Group: * 12-18 years of age * No history of suicide attempt Exclusion Criteria: Suicide Attempt Study Group: * History of autism spectrum disorder * Non-verbal * Moderate or severe intellectual disability (IQ\<70 and patients in special education full-time) * Schizophrenia or schizoaffective disorder diagnosis * Current diagnosis of anorexia or bulimia * History of generalized tonic-clonic epileptic seizures in last 3 months (If patient does not have a history of seizures, and generalized tonic-clonic seizure was clinically determined to be caused by patient's recent overdose attempt, patient can still be recruited for study if 24 hours has passed since last seizure) * History of traumatic brain injury, brain tumor, or any major neurological disorder * Delirium or mood disorder secondary to general medical condition * Current infection, fever, antibiotic use in the last 2 weeks * History of autoimmune or immunodeficiency diseases * Current untreated major endocrine disorder * Current pregnancy or delivery within the last month * Diagnosed malnutrition * Positive urine toxicology for benzodiazepines or opiates on admission * Current substance use disorder diagnosis and referral for CD assessment upon discharge * Current diagnosis of morbid obesity or a current BMI greater than 40 kg/m2 * Abnormal complete blood count (CBC) Healthy Control Group: * History of any psychiatric diagnosis / treatment (behavioral diagnoses \[ADD/ADHD/etc\] are okay) * History of suicidal ideation, behavior, or attempt * Family history of suicide attempts * Diagnosis of schizophrenia or bipolar disorder in parents or siblings * History of autism spectrum disorder * Moderate or severe intellectual disability (IQ\<70 and patients in special education full-time) * History of generalized tonic-clonic epileptic seizures in last 3 months * History of headaches or migraines in the last month * History of traumatic brain injury, brain tumor, or any major neurological disorder * Delirium or mood disorder secondary to general medical condition * Current infection, fever, antibiotic use in the last 2 weeks * History of autoimmune or immunodeficiency diseases * Current untreated major endocrine disorder * Current pregnancy or delivery within the last month * Diagnosed malnutrition * Report of any substance use in week prior
References
Publications (0)
Data not yet available
No reference posted for this study.