Clinical trial · Interventional
Glucobrassicin-Brussel Sprout Effect on D10 Phe Metabolism
Assessing the Effect of Glucobrassicin-Rich Brussels Sprouts on the Metabolism of Deuterated Phenanthrene: Developing Food-Based Chemoprevention of Tobacco-Related Lung Cancer
NCT02999399CI-TRIAL-00064042completedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To determine whether glucobrassicin-rich Brussels sprouts can favorably modify the metabolism of the polycyclic aromatic hydrocarbon deuterated phenanthrene (\[D10\]phe) in current and former smokers
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Smoking | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Brussel Sprouts | Other | — | UNRESOLVED |
| Deuterated Phenanthrene | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- [D10]phe and Brussels sprouts
- description
- All subjects are given 1 microgram \[D10\]phe before and after consuming Brussels sprouts once daily for 7 consecutive days.
- interventionNames
- Other: Brussel Sprouts
- Drug: Deuterated Phenanthrene
Primary outcomes (1)
- measure
- Change in [D10]phenanthrene tetraol
- timeFrame
- 7 days
- description
- Compare level of urinary \[D10\]phenanthrene tetraol before and after 7 days of Brussels sprout consumption.
Secondary outcomes (2)
- measure
- Change in [D10]phenanthrols
- timeFrame
- 7 days
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * Adult ≥ 18 years old * Current or former smoker by self-report * Willing to abstain from cruciferous vegetable consumption other than the study vegetable during the study period * Able to understand the experimental nature of the study and provide informed consent * Negative urine pregnancy test for women of childbearing potential within 7 days of baseline \[D10\]phe dosing Exclusion Criteria: * Chronic proton pump inhibitor, H2-blocker (i.e., ranitidine, famotidine), and/or calcium carbonate use * History of gastric bypass surgery, gastric banding, bowel resection, malabsorption syndromes such as celiac sprue or pancreatic insufficiency, or other conditions that may affect gastric absorption * Current use of tobacco products other than cigarettes (i.e. snuff, snuz, smokeless tobacco, cigars, pipes) or use of these products within 3 months of study registration * Major or chronic medical disease, including heart disease, poorly controlled diabetes, etc., to be adjudicated by the principal investigator * Women who are pregnant, intend to become pregnant within 3 months of the study period, or who are breastfeeding * Current or recent (within 12 months) problems with drug use or alcohol dependence by self-report Antibiotic use within 2 months of study enrollment or during the study by self-report Alcohol dependence, abuse, or history of dependence/abuse by self-report Vegetarians * History of respiratory tract cancer * Use of metronidazole or antabuse during the study * Taking ibuprofen, naproxen, other NSAIDs, steroids (except inhaled steroids) within 14 days of study registration * Allergy to Brussels sprouts
References
Publications (0)
Data not yet available
No reference posted for this study.