Clinical trial · Interventional
Exercise Effect on Chemotherapy-Induced Neuropathic Pain
Exercise Effect on Chemotherapy-Induced Neuropathic Pain, Peripheral Nerve Fibers
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Chemotherapy-induced peripheral neuropathy (CIPN) continues to be a serious healthcare concern. It is painful, persistent, resistant to conventional pain therapies, and results in long-term suffering and decreased quality of life for many cancer survivors. The role of exercise to decrease CIPN-related neuropathic pain (CIPN-NP) will be investigated, with the goal of identifying the mechanisms associated with this therapeutic approach to manage CIPN-NP.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer, Breast | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Cancer, Colorectal | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Cancer, Lung | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Cancer, Ovarian | Malignant Ovarian Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| aerobic exercise intervention | Behavioral | — | UNRESOLVED |
| control group | Other | — | UNRESOLVED |
| resistive training | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- OTHER
- label
- control
- description
- This is an attention control group with regular contact by study staff.
- interventionNames
- Other: control group
- type
- EXPERIMENTAL
- label
- aerobic exercise
- description
- Aerobic exercise intervention is for 12 weeks 3 times weekly with training on site.
- interventionNames
- Behavioral: aerobic exercise intervention
- type
- EXPERIMENTAL
- label
- resistive training
- description
- Intervention is for 12 weeks 3 times weekly with training on site.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 21 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Diagnosis with cancer, stage I-IV * History of treatment with oxaliplatin, docetaxel, or paclitaxel, either alone or in combination with other agents * Completion of chemotherapy \> 6 months \< 1 year * Ability to walk on a treadmill * Medical clearance from oncologist or primary care provider * Presence of CIPN per National Cancer Institute Common Toxicity Criteria grade 1-3 (0-no signs/symptoms, 1-minor loss of function, 2-increased symptoms not interfering with activities of daily living (ADLs), 3-severe symptoms interfering with ADL, 4-disabling, and 5 is death) * Score on Neuropathic Pain Scale \>1 * Age 21-70 Exclusion Criteria: * Denial of CIPN * Other motor/sensory neuropathy caused by other than chemotherapy (i.e.alcohol-related, autoimmune diseases, diabetes) * Coronary artery disease * History of \>1 chemotherapy regimen * Musculoskeletal conditions which preclude participation in an exercise training program * Pregnancy * Regular exerciser, defined as \>90 minutes per week of aerobic exercise and any resistive training
References
Publications (0)
Data not yet available