Clinical trial · Observational
Safety Margin Assessment After RFA Using the Registration of Pre-ablation MRI and Post-ablation CT
Prospective Evaluation of Local Tumor Progression After Radiofrequency Ablation of Hepatocellular Carcinoma: Effectiveness of Immediate Second-Look Evaluation Using Pre-RFA MRI and Post-RFA CT Registration
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Magnetic resonance imaging (MRI) has been widely used for small liver lesion detection and characterization. In patients who undergo RFA, MRI is often performed before RFA, whereas immediate technical success is usually assessed by CT. Conventional visual assessment of two modalities may be more challenging than being anticipated, because acquisition position, respiration, and spatial resolution differ between the two. Therefore, the study purpose is to evaluate the results of software-assisted ablative margin assessment using registration of different pre-and post-RFA modalities compared with the conventional method of side-by-side MRI-CT comparison in patients with HCCs.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| HCC | Hepatocellular Carcinoma | PROBABILISTIC | 0.70 |
| Liver Tumor | Liver Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| RFA | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Local tumor progression (LTP)
- timeFrame
- 60 months
- description
- 5-year-LTP rate in HCC between sufficient and insufficient ablative margin groups (according to visual assessment and registration software-assisted assessment)
Secondary outcomes (3)
- measure
- technique efficacy
- timeFrame
- 1 month after RFA
- description
- Rate of absence of viable tumor on 1-months follow-up CT scan.
- measure
- immediate technical success on visual assessment
- timeFrame
- 1 day after RFA
- description
- technical success of RFA on post-RFA CT using side-by-side comparison of pre-RFA MRI and post-RFA CT
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients (≥ 18 years) who were referred to our radiology department for liver tumor RFA * patients who had liver MR images of sufficient quality for pre-RFA evaluation within 30 days before RFA * patients with 1-3 tumors (\<5 cm) Exclusion Criteria: * Child-Pugh class C * any uncorrected coagulopathy * hypersensitivity to iodine or other reasons that prevented the performance of post-RFA contrast-enhanced CT
References
Publications (0)
Data not yet available