Clinical trial · Interventional
CBCT in Guiding Bronchoscopy in Patients With Lung Lesions
A New Guide for Our Guided-Bronchoscopy: The Use of Cone-Beam CT to Enhance Navigation and Diagnostic Yield of RP-EBUS and Hybrid Bronchoscope for Peripheral Lung Nodules Suspicious for Malignancy: A Pilot Study
NCT02978170CI-TRIAL-00038920completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This pilot clinical trial studies how well cone-beam computed tomography (CBCT) works in guiding bronchoscopy in patients with lung lesions. CBCT during bronchoscopy may help doctors to biopsy lung lesions that are harder to reach.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Pulmonary Mass | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Cone-Beam Computed Tomography | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic (CBCT)
- description
- Patients undergo CBCT during standard of care bronchoscopy.
- interventionNames
- Procedure: Cone-Beam Computed Tomography
Primary outcomes (1)
- measure
- Feasibility based on percentage of patients where researchers can locate target and bronchoscopic tools with cone-beam computed tomography
- timeFrame
- Up to 6 months
- description
- Will be considered feasible if researchers can locate target and bronchoscopic tools with cone-beam computed tomography in at least 80% of the patients (16 out of the 20 participants) that are enrolled.
Secondary outcomes (5)
- measure
- Proportion of patients with peripheral nodules undergoing bronchoscopy in different subsample
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients undergoing guided-bronchoscopy for diagnosis of peripheral lung lesion/s \> 1 and \< 3 cm in diameter located in the outer 2/3 of the lung fields Exclusion Criteria: * Pregnant or breastfeeding women * Patient with indications for mediastinal lymph node (LN) sampling per 13th American College of Clinical Pharmacy (ACCP) guidelines * Patient with metastatic disease (from primaries other than lung) who have suspicious mediastinal or hilar LN that require sampling * Patients with contraindication/s for general anesthesia (e.g., severe and active coronary artery disease, chronic obstructive pulmonary disease \[COPD\] with forced expiratory volume in 1 second \[FEV1\] \< 1 liter, uncontrolled hypertension, increased intracranial pressure, history of intolerance to general anesthesia) * Dementia or other severe cognitive impairment causing inability to understand or consent to the procedure and study
References
Publications (1)
- DERIVEDCasal RF, Sarkiss M, Jones AK, Stewart J, Tam A, Grosu HB, Ost DE, Jimenez CA, Eapen GA. Cone beam computed tomography-guided thin/ultrathin bronchoscopy for diagnosis of peripheral lung nodules: a prospective pilot study. J Thorac Dis. 2018 Dec;10(12):6950-6959. doi: 10.21037/jtd.2018.11.21. PMID 30746241