Clinical trial · Observational
Short Term Genetic Effects of Chemotherapy on Male Germ Cells
NCT02975245CI-TRIAL-00095483completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study will determine the short-term effects of chemotherapy on sperm DNA.The study involves the collection of semen sample through ejaculation prior to initiation of chemotherapy and up to three time points after initiation of chemotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Semen collection and analysis | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Men receiving chemotherapy
- description
- Semen collection and analysis
- interventionNames
- Procedure: Semen collection and analysis
Primary outcomes (1)
- measure
- the differences in DNA between sperm collected before chemotherapy to sperm collected after the first round of chemotherapy using whole exome sequencing.
- timeFrame
- 5 years
- description
- Sperm count test analyzes the health and viability of sperm, as it takes into account sperm number, motility, and morphology.
Secondary outcomes (1)
- measure
- changes in sperm quality from sperm collected before the initiation of chemotherapy to sperm collected after first round of chemotherapy using sperm count test.
- timeFrame
- 5 years
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
- Maximum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Be scheduled to undergo treatment with chemotherapeutic agents for a medical indication * Be able to produce semen samples prior to chemotherapy and one week after first round of chemotherapy Exclusion Criteria: * Men who have previously been treated with chemotherapeutic agents. * Men with significant oligospermia or azospermia.
References
Publications (0)
Data not yet available
No reference posted for this study.