Clinical trial · Observational
Oncological Care for Patients With Meningioma
Postoperative Oncological Care for Patients With Meningioma With Malignant Components
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Meningiomas with malignant components include grade II meningiomas (GIIM, the most common ones) and grade III meningiomas (GIIIM). They represent 5-35% of all meningiomas. Histological diagnosis of GIIM criteria were changed in 2007 and might be viewed by some as being quite subjective. "Standards of care" and consensus do not exist for GIIM, particularly in regards to performing, or not, radiotherapy after surgery. One other limitation in the literature is lack of data on health-related quality of life (HRQoL). Clinical trials for GIIM are very difficult to conduct. No results have been made available. Here, we propose to study clinical, pathological, radiological and therapeutic factors of an exhaustive population of GIIM and GIIIM patients, at national level. The main objective (for GIIM) is to assess the impact of postoperative radiotherapy, or the absence of postoperative radiotherapy, on overall survival and on quality of life
Conditions
Conditions (6)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anaplastic Meningioma | Anaplastic (Malignant) Meningioma | ALIAS | 0.90 |
| Atypical Meningioma | Atypical Meningioma | ONTOLOGY_EXACT | 0.90 |
| Chordoid Meningioma | Chordoid Meningioma | ONTOLOGY_EXACT | 0.98 |
| Clear-cell Meningioma | Clear Cell Meningioma | ONTOLOGY_EXACT | 0.98 |
| Papillary Meningioma | Papillary Meningioma | ONTOLOGY_EXACT | 0.90 |
| Rhabdoid Meningioma | Rhabdoid Meningioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- overall survival
- timeFrame
- up to 10 years, since diagnosis
- description
- Description: Assessing the impact of postoperative radiotherapy after surgery on overall survival (OS) in population-based study of GIIM patients. Overall survival, the primary endpoint of this study, is defined as the time from surgery (histological diagnosis) to the time of death from any cause. Alive Patients at the time of the final analysis or who became lost to follow-up will be censored at their last date of giving news
Secondary outcomes (2)
- measure
- the tumor growth
- timeFrame
- up to 10 years, since diagnosis
- description
- The tumor growth after surgery and other treatment (based on successive MRIs) will be determined by the volumetric velocity of the tumor growth (mm3/year)
- measure
- Progression/Recurrence Free Survival, will be measured by month
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria :Patient with a GIIM incident (atypical, chordidic and clear cell meningiomas) and GIIIM (anaplastic, papillary and rhabdoid meningiomas) operated in metropolitan France during the period 2007-2010 Exclusion Criteria : * Patient with GIM * Non-operated meningioma patient
References
Publications (0)
Data not yet available