Clinical trial · Interventional
Psychological Evaluation According Colonic Colonization by Escherichia Coli of Patients After Colorectal Surgery
NCT02970513CI-TRIAL-00120701MicrobioPSYcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine whether the presence of pathogenic Escherichia coli in colon is associated with psychiatric disorders.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Psychiatric evaluation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- patients operated on for colorectal cancer
- interventionNames
- Other: Psychiatric evaluation
Primary outcomes (1)
- measure
- Hamilton anxiety and depression score comparison
- timeFrame
- at day 1
- description
- Hamilton anxiety and depression score will be compared between patients with Escherichi coli colonic colonization and patients without Escherichi coli
Secondary outcomes (2)
- measure
- Psychiatric prevalence comparison
- timeFrame
- at day 1
- description
- prevalence of each past and actual psychiatric disorder diagnosed by the Mini International Neuropsychiatric Interview (MINI: major depression, dysthymia, suicidal risk, hypomania, mania, panic disorder, agoraphobia, social phobia, specific phobia, obsessive-compulsive disorder, posttraumatic stress disorder, dependence and abuse of alcohol, tobacco- dependence, psychotic disorders and generalized anxiety disorder) will be compared in patients according to colonic colonization by Escherichia coli.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * patients operated on for colorectal cancer in the digestive surgery department of Clermont-Ferrand hospital * patients older than 18 years, * patients whose Escherichia coli colonization was analyzed after surgery * patients which are always followed by the digestive surgery department. Exclusion Criteria: * Patients with dementia will not be included, according to the MMSE score: * 22 if no grade * 23 if study certificate or CAP or college without patent * 25 if patent or school without the tray * 26 or more when bin
References
Publications (1)
- RESULTRondepierre F, Meynier M, Gagniere J, Deneuvy V, Deneuvy A, Roche G, Baudu E, Pereira B, Bonnet R, Barnich N, Carvalho FA, Pezet D, Bonnet M, Jalenques I. Preclinical and clinical evidence of the association of colibactin-producing Escherichia coli with anxiety and depression in colon cancer. World J Gastroenterol. 2024 Jun 7;30(21):2817-2826. doi: 10.3748/wjg.v30.i21.2817. PMID 38899326