Expanded Access Program of Ultratrace Iobenguane I131 for Malignant Relapsed/Refractory Pheochromocytoma/Paraganglioma

Inclusion Criteria:

* Able and willing to provide informed consent/assent and comply with protocol requirements
* Documented diagnosis of either pheochromocytoma or paraganglioma that was confirmed by histology or other supportive data (e.g. abnormal MIBG diagnostic study or elevated tumor markers)
* Ineligible for curative surgery for PPGL
* Failed a prior therapy for PPGL or have no alternative indicated therapy available
* Have definitive tumor avidity confirmed by the AZEDRA dosimetry dose
* Life expectancy of at least 6 months per physician

Exclusion Criteria:

* Pregnant or nursing females
* Men or women of childbearing potential and unwilling to use a medically acceptable form of contraception from time of consent until 6 months following last therapeutic dose of AZEDRA
* Active CNS lesions by CT/MRI within 3 months of informed consent
* NYHA class IV heart failure, unstable angina pectoris or clinically significant cardiac arrhythmia that poses a risk of syncope or cardiac arrest
* Prior systemic radiotherapy resulting in marrow toxicity within 3 months of first AZEDRA therapeutic dose
* Prior iobenguane I 131 therapeutic exposure within 12 weeks of the first planned therapeutic dose
* Prior administration of whole-body radiation therapy within 12 weeks of the first planned therapeutic dose
* Prior external beam radiotherapy to \> 25% of bone marrow
* Prior chemotherapy or investigational compound and/or device within 30 days of the dosimetry dose
* Other active malignancy requiring additional treatment except for superficial cutaneous neoplasms
* Karnofsky Performance Status \< 60
* Clinically significant laboratory abnormalities prior to dosing as listed in the protocol (such as blood count abnormalities, liver enzyme abnormalities, and renal dysfunction)
* Medical history of AIDS/HIV+
* Active chronic alcohol abuse, chronic liver disease (not including liver metastases), hepatitis A, B, or C
* Known allergy to iobenguane that has required medical intervention
* Receiving a medication which inhibits tumor uptake of iobenguane I 131
* Any other condition, that in the opinion of the investigator, may compromise the safety or compliance of the subject