Clinical trial · Interventional
Significance of Circulating Tumor Cells in the Treatment of Gastric and Rectal Cancer
Significance of Circulating Tumor Cells (CTC) Detected by the CTCBIOPSY System as Potential Blood-based Biomarkers in Providing Prognostic and Predictive Information for Surgical Treatment of Gastric and Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The primary purpose of this study is to compare both short-term and long-term treatment effect of laparoscopic vs. open approach on progressive gastric and rectal cancer, based on circulating tumor cell (CTC) test results as well as disease-free survivals, and figure out principles of laparoscopic approach for progressive gastric and rectal cancer. Secondary purpose is to establish an evaluation system for laparoscopic surgery for progressive gastric and rectal cancer treatment using CTC as a biomarker.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Circulating Tumor Cells | — | UNRESOLVED | — |
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Surgery | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- EXPERIMENTAL
- label
- Open surgery of rectal cancer
- description
- Patients undergoing rectal cancer resection in an open approach
- interventionNames
- Procedure: Surgery
- type
- EXPERIMENTAL
- label
- Laparoscopic surgery of rectal cancer
- description
- Patients undergoing rectal cancer resection in a laparoscopic approach
- interventionNames
- Procedure: Surgery
- type
- EXPERIMENTAL
- label
- Open surgery of gastric cancer
- description
- Patients undergoing gastric cancer resection in an open approach
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Gastric cancer Inclusion Criteria: * Gastric cancer of stage II/III Exclusion Criteria: * History of malignant tumors * Gastric cancer of stage Ⅳ * Preoperative neoadjuvant chemotherapy * History of upper abdominal surgery * Severe other contradictions of surgery Rectal cancer Inclusion Criteria: * Primary rectal carcinoma * Single lesion * No metastasis * Sphincter-saving surgery available Exclusion Criteria: * History of malignant tumors * Acute bowel obstruction, bleeding or perforation * Tumor over 6cm in diameter or in severe adhesion with surrounded tissues * Severe other contradictions of surgery
References
Publications (2)
- BACKGROUNDBenson AB 3rd, Venook AP, Bekaii-Saab T, Chan E, Chen YJ, Cooper HS, Engstrom PF, Enzinger PC, Fenton MJ, Fuchs CS, Grem JL, Grothey A, Hochster HS, Hunt S, Kamel A, Kirilcuk N, Leong LA, Lin E, Messersmith WA, Mulcahy MF, Murphy JD, Nurkin S, Rohren E, Ryan DP, Saltz L, Sharma S, Shibata D, Skibber JM, Sofocleous CT, Stoffel EM, Stotsky-Himelfarb E, Willett CG, Gregory KM, Freedman-Cass D. Rectal Cancer, Version 2.2015. J Natl Compr Canc Netw. 2015 Jun;13(6):719-28; quiz 728. doi: 10.6004/jnccn.2015.0087. PMID 26085388
- BACKGROUNDLowes LE, Bratman SV, Dittamore R, Done S, Kelley SO, Mai S, Morin RD, Wyatt AW, Allan AL. Circulating Tumor Cells (CTC) and Cell-Free DNA (cfDNA) Workshop 2016: Scientific Opportunities and Logistics for Cancer Clinical Trial Incorporation. Int J Mol Sci. 2016 Sep 8;17(9):1505. doi: 10.3390/ijms17091505. PMID 27618023