Clinical trial · Observational
Chronic Periodontitis and Polycystic Ovary Syndrome
Evaluation Of Lipid Peroxidation, Oxidative DNA Damage And Total Antioxidant Status In Patients With Periodontitis And Polycystic Ovary Syndrome: A Cross Sectional Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: The aim of this study was to investigate the levels of malondialdehyde (MDA), total antioxidant status (TAS), 8-hydroxy-2´- deoxyguanosine (8-OHdG) in blood serum and saliva samples in female patients with chronic periodontitis (CP) and to compared healthy individuals. Materials and Methods: A total of 88 women were into four groups each which were consisted of twenty-two subjects. Groups were designed as periodontally and systemically healthy women (PCOS-CP-); periodontally healthy women with polycystic ovary syndrome (PCOS) (PCOS+CP-), systemically healthy women with CP (PCOS-,CP+) and women with PCOS and CP (PCOS+CP+). Serum and salivary samples were obtained, clinical periodontal parameters were recorded. MDA, TAS, 8-OHdG levels were measured as biochemically.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Chronic Periodontitis | — | UNRESOLVED | — |
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| no intervention provided | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- label
- (PCOS-CP-)
- description
- systemically and periodontally healthy participants
- interventionNames
- Other: no intervention provided
- label
- (PCOS-CP+)
- description
- systemically healthy participants with CP
- interventionNames
- Other: no intervention provided
- label
- (PCOS+CP-)
- description
- PCOS participants with periodontally healthy
- interventionNames
- Other: no intervention provided
- label
- (PCOS+CP+)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: * Newly diagnosed non-obese PCOS patients * Never smokers * Had no history of systemic disease * BMI\<25 kg/m2 * Participants had ≥20 teeth present. Exclusion Criteria: * Pregnancy * Lactation * Hemoglobin A1c (HbA1c) ≥ 6.5% * 2-h oral glucose tolerance test (OGTT-2h) ≥200 * Cushing syndrome, non-classic congenital adrenal hyperplasia, hyperprolactinemia, thyroid dysfunction, and androgen-secreting tumors * Any drug use within the past 6 months * Periodontal treatment within the past 6 months
References
Publications (0)
Data not yet available