Biodistribution/Reproducibility Ga-68 PSMA-HBED-CC

There will be no control group. For the study group the following inclusion and exclusion criteria will be followed.

INCLUSION CRITERIA

* Male
* Aged ≥ 18 years
* Histological diagnosis of adenocarcinoma of the prostate OR have a clinical diagnosis of prostate cancer and on active therapy or have received treatment for prostate cancer.
* Multifocal metastatic disease in either castrate sensitive or castrate resistant patients.
* May or may not be on hormonal therapy, chemotherapy, or radium therapy.
* If on hormonal therapy or chemotherapy, must be on it for at least 3 months.
* No plans to undergo prostate cancer therapy administration (with hormone therapy, chemotherapy, radium therapy, external radiation) between the two study exams.
* At least 2 metastatic soft tissue or bone lesions identified on conventional imaging (CT, MRI or bone scan).
* Karnofsky performance status of ≥ 50 (or ECOG/WHO equivalent)
* Ability to understand and willingness to sign a consent document.

EXCLUSION CRITERIA

* Uncontrolled intercurrent illness including, but not limited to ongoing or active infection requiring hospitalization, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
* Physical limitation that would limit compliance with the study requirements
* Current enrollment in a therapeutic clinical trial