Clinical trial · Interventional
A Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach
A Prospective Randomized Controlled Clinical Study of Laparoscopic Right Hemicolectomy Using the Caudal-to-cranial Approach
NCT02949440CI-TRIAL-00024508LRHCTC-1unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To investigate the clinical application value of laparoscopic radical right hemicolectomy using the caudal-to-cranial approach versus the medial-to-lateral approach by prospective randomized controlled clinical study.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenocarcinoma of Hepatic Flexure (Diagnosis) | — | UNRESOLVED | — |
| Ascending Colon Cancer | — | UNRESOLVED | — |
| Cancer Flexure Hepatic | — | UNRESOLVED | — |
| Ileocaecal Valve Carcinoma | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| the caudal-to-cranial approach | Procedure | — | UNRESOLVED |
| the medial-to-lateral approach | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- the caudal-to-cranial approach
- description
- Cutting the peritoneum along the line between the right mesocolon and retroperitoneum, enter the Toldt's space to dissect the posterior of Superior mesenteric vein（SMV）and Superior mesenteric artery（SMA）and their branches, and then finished the D3 dissection from caudal to cranial on both sides of the mesentery along the Superior mesenteric vein（SMV）. In the end, cut the lateral ligament to mobilize the posterior space of ascending colon. This approach is called caudal-to-cranial approach.
- interventionNames
- Procedure: the caudal-to-cranial approach
- type
- ACTIVE_COMPARATOR
- label
- the medial-to-lateral approach
- description
- First, the pedicle of ileocolic vessels is identified and the mesocolon is dissected between the pedicle and the periphery of the Superior mesenteric vein（SMV）to expose the second portion of the duodenum. The ileocolic vessels are then cut at their roots. The ascending mesocolon is separated from the retroperitoneal tissues, duodenum, and pancreatic head up to the hepatocolic ligament cranially. The important detail in this procedure is the wide separation between the pancreatic head and the transverse mesocolon.This approach is the medial-to-lateral(MtL) approach
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. The age limits is 18-80 years old; 2. The clinical staging was II,III carcinoma of right colon，located in right-sided colon; 3. The preoperative imaging confirmed that the tumor did not involve adjacent organs; 4. American Society of anesthesiologists (ASA) score less than or equal to Level III; 5. Criteria of performance status karnofsky is greater than or equal to 60. Exclusion Criteria: 1. The patients' age limits is Less than 18 years old, or more than 80 years old 2. The preoperative imaging confirmed that the tumor involve adjacent organs; 3. The tumor have been finding distant metastases; 4. American Society of anesthesiologists (ASA) score more than 3; 5. Criteria of performance status karnofsky is lower than 60; 6. It is the carcinoma of right colon with multiple colonic polyps Disease; 7. there is a laparoscopic surgery contraindications.
References
Publications (3)
- RESULTZou L, Xiong W, Li H, He Y, Diao D, Zheng Y, Luo L, Tan P, Wang W, Wan J. [Efficacy analysis of laparoscopic radical right hemicolectomy using caudal-to-cranial approach]. Zhonghua Wei Chang Wai Ke Za Zhi. 2015 Nov;18(11):1124-7. Chinese. PMID 26616807
- RESULTZou L, Xiong W, Mo D, He Y, Li H, Tan P, Wang W, Wan J. Laparoscopic Radical Extended Right Hemicolectomy Using a Caudal-to-Cranial Approach. Ann Surg Oncol. 2016 Aug;23(8):2562-3. doi: 10.1245/s10434-016-5215-2. Epub 2016 Apr 12. PMID 27072997
- RESULTLi H, He Y, Lin Z, Xiong W, Diao D, Wang W, Wan J, Zou L. Laparoscopic caudal-to-cranial approach for radical lymph node dissection in right hemicolectomy. Langenbecks Arch Surg. 2016 Aug;401(5):741-6. doi: 10.1007/s00423-016-1465-5. Epub 2016 Jun 18. PMID 27318491