Clinical trial · Interventional
Effectiveness of Nefopam in Breast Cancer Surgery
NCT02949310CI-TRIAL-00031142unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Breast cancer surgery is known to cause severe acute postoperative pain, which can persist for a long time. The investigators administered nefopam preventively to patients undergoing total mastectomy or modified radical mastectomy with axillary lymph node dissection or sentinel lymph node biopsy, and evaluated its efficacy on acute and chronic postoperative pain.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Neoplasm Malignant Primary | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Nefopam | Drug | — | UNRESOLVED |
| Normal Saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- Control
- description
- Placebo use instead of nefopam
- interventionNames
- Drug: Normal Saline
- type
- EXPERIMENTAL
- label
- Nefopam
- description
- Intraoperative use of nefopam 40 mg
- interventionNames
- Drug: Nefopam
Primary outcomes (1)
- measure
- Change of cumulative analgesia volume infused via intravenous patient-controlled analgesia device
- timeFrame
- At postoperative 4 hour, 24 hour, 48 hour, 72 hour, 10 day, and 3 month
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
Show eligibility criteria text
Inclusion Criteria: * Total mastectomy * Modified radical mastectomy * Nipple-sparing mastectomy * American Society of Anesthesiologists physical status I or II * Postoperative use of intravenous patient-controlled analgesia Exclusion Criteria: * Chronic analgesia medication * Pregnancy * Lactating women * Previous operation history due to breast cancer * Cooperation with other surgery * Contraindication of nefopam
References
Publications (0)
Data not yet available
No reference posted for this study.