Clinical trial · Interventional
Proton/Photon Rt - Benign Meningiomas(P92-13)
Prospective Study Of Patients With Recurrent Or Incomplete Excised Benign Intercranial Meningiomas For The Evaluation Of Treatment Result With Combined Proton And Photon Irradiation To Doses 55.8 Or 63.0 CGE
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to determine the best radiation dose for participants with meningioma that has grown back after previous surgery, or which the surgeon has been unable to remove completely. This research study is designed to determine whether a higher dose of radiation will decrease the likelihood that the tumor will grow back, compared to the probability of re-growth that occurs after standard radiation doses.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Benign Meningioma | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Higher Dose | Radiation | — | UNRESOLVED |
| Standard Treatment | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Standard Treatment
- description
- Standard radiation therapy: 55.8 CGE in 31 treatments of 1.8 CGE given once a day, for five days each week.
- interventionNames
- Radiation: Standard Treatment
- type
- EXPERIMENTAL
- label
- Higher Dose Treatment
- description
- 63 CGE in 35 treatments of 1.8 CGE given once a day, for five days of each week.
- interventionNames
- Radiation: Higher Dose
Primary outcomes (1)
- measure
- Progression Free Survival
- timeFrame
- 5, 10, 15 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age 18 or over * Histological documentation of benign meningioma * Documentation by imaging studies (CT and/ or MRI) or residual or recurrent intracranial tumor * Karnofsky performance status of ≥ 70 * Study specific informed consent Exclusion Criteria: * Malignant meningiomas * Prior cranial irradiation, except treatment of localized skin cancer of the face or scalp * Patients having a concurrent primary cancer (except skin) * Patients having another cancer controlled \< 3 years * Pregnant patients
References
Publications (0)
Data not yet available