Clinical trial · Observational
Investigation of the Role of the Microbiome in the Pathogenesis of Colorectal Adenoma and Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is the investigation of new host-microbiome interactions promoting adenoma formation and adenocarcinoma progression. For that purpose, the investigators will collect saliva, stool and colon biopsy specimens from patients referred to colonoscopy or surgical resection of colorectal tumor. Besides, a questionnaire about diet, lifestyle and medical history will be collected. Sample analysis will involve simultaneous characterization of host and microbiota genomic and transcriptomic components.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Adenoma and Carcinoma | Colorectal Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colon biopsies | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Healthy control
- description
- Patients undergoing lower GI endoscopy without any colorectal adenoma or carcinoma.
- interventionNames
- Procedure: Colon biopsies
- label
- Adenoma
- description
- Patients undergoing lower GI endoscopy with presence of colorectal adenoma detected.
- interventionNames
- Procedure: Colon biopsies
- label
- Colorectal cancer
- description
- Patients diagnosed with colorectal cancer and referred to surgical carcinoma resection.
- interventionNames
- Procedure: Colon biopsies
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Lower GI endoscopy patients Inclusion Criteria: * Participant is willing and able to give informed consent for the participation in the study before any protocol-specific screening procedures are performed * Male or female, aged 18 years or above * Referred to lower GI endoscopy. Referral reasons can be among others: * Positive FOBT (Fecal Occult Blood Test) * Follow up after polypectomy * Screening because of age * Bleeding * Abdominal pain * Familial or past history of colon cancer or adenoma * Abnormal imaging such as barium enema * Change in bowel habits * Both self-referrals, referrals from external GP or specialists and internal referrals can be included. Exclusion Criteria: * Previous diagnosis of an inflammatory bowel disease * Previous diagnosis of intestinal polyposis syndrome CRC patients Inclusion criteria: * Participant is willing and able to give informed consent for the participation in the study before any protocol-specific screening procedures are performed * Male or female, aged 18 years or above * Diagnosis of CRC for which resection is planned * Both internal and external referrals from specialists can be included Exclusion Criteria: * Previous diagnosis of an inflammatory bowel disease * Previous diagnosis of intestinal polyposis syndrome
References
Publications (0)
Data not yet available