Clinical trial · Interventional
Molecular Testing to Direct Extent of Initial Thyroid Surgery
NCT02947035CI-TRIAL-00068002completedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research study consists of the participant agreeing to 1) the use of preoperative molecular testing (ThyroSeq) to guide extent of initial surgery and 2) the prospective collection of medical record data related to treatment of thyroid cancer.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Thyroid Cancer | Malignant Thyroid Gland Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Thyroid lobectomy | Procedure | — | UNRESOLVED |
| Total thyroidectomy with CCND | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Low Risk
- description
- Molecular testing and ultrasound features will be used to predict if thyroid cancer is low risk. Intervention will be to perform thyroid lobectomy.
- interventionNames
- Procedure: Thyroid lobectomy
- type
- EXPERIMENTAL
- label
- High Risk
- description
- Molecular testing and ultrasound features will be used to predict if thyroid cancer is high risk. Intervention will be to perform more aggressive surgery to include total thyroidectomy with CCND.
- interventionNames
- Procedure: Total thyroidectomy with CCND
Primary outcomes (1)
- measure
- Number of patients who require completion thyroidectomy for aggressive histology features
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Thyroid nodule is \>1.5 cm * Preoperative FNA biopsy that is positive for papillary thyroid cancer or suspicious for papillary thyroid cancer Exclusion Criteria: * Prior thyroid/parathyroid surgery * Clinical indications for total thyroidectomy including hypothyroidism, history of head or neck radiation when \<18 years old * Recurrent laryngeal nerve dysfunction * Diagnosis of concurrent primary hyperparathyroidism
References
Publications (0)
Data not yet available
No reference posted for this study.