Clinical trial · Interventional
Precision Diagnosis for Intraoperative Frozen Section of Early Stage Lung Cancer
Establishment and Evaluation for Pathological Diagnostic Criteria of Intraoperative Frozen Section of Early Stage Lung Cancer
NCT02941003CI-TRIAL-00024481unknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is: 1. To establish a set of diagnostic criteria of intraoperative frozen section of early stage lung adenocarcinoma, including clinicopathologic and molecular characteristics. 2. To assess its clinical usefulness in guiding surgical procedure for early stage lung adenocarcinoma.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| immunostaining | Other | — | UNRESOLVED |
| microscope | Device | — | UNRESOLVED |
| NGS | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- OCT treatment
- description
- Randomly assigned patients whose small pulmonary nodules are inflated with the diluted OCT medium (2:3) used for frozen section, and then detected under microscope for their histopathological characteristics, by immunostaining for specific protein expression, by NGS (next-generation sequencing) for driver mutations.
- interventionNames
- Device: microscope
- Other: immunostaining
- Device: NGS
- type
- EXPERIMENTAL
- label
- OCT free
- description
- Randomly assigned patients whose small pulmonary nodules are uninflated with OCT used for frozen section, and then detected under microscope for their histopathological characteristics, by immunostaining for specific protein expression, by NGS for driver mutations.
- interventionNames
- Device: microscope
- Other: immunostaining
- Device: NGS
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 40 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with suspected pulmonary nodules (5\~20 mm) by chest CT scan; 2. Patients received surgical operation. Exclusion Criteria: 1. Patients compliance is poor and cannot accept follow-up; 2. Patients nursing or pregnant; 3. Patients with a history of any cancer; 4. Patients with confirmed pathological diagnosis or received radiotherapy or chemotherapy or target therapy preoperatively.
References
Publications (0)
Data not yet available
No reference posted for this study.