Clinical trial · Interventional
Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer
Multi-center Phase II Clinical Randomized Study of Chronomodulated Chemotherapy Followed by Concurrent Chemo-radiotherapy With IMRT in the Treatment of Advanced Nasopharyngeal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
1. Observe and compare the chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy term efficacy of the treatment of locally advanced nasopharyngeal carcinoma. 2. Evaluation chrono-chemotherapy IMRT and conventional chemotherapy and intensity modulated radiotherapy in locally advanced nasopharyngeal carcinoma safety and tolerability. 3）observing the adverse reaction and effects of two groups,expected chrono-chemotherapy group can achieve lower toxicity, improve the curative effect, for the treatment of nasopharyngeal carcinoma provides a more reasonable way.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Neoplasms | Esophageal Neoplasm | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (7)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Chrono-chemotherapy pump:Melodie | Device | — | UNRESOLVED |
| cisplatin chrono-chemotherapy | Drug | — | UNRESOLVED |
| cisplatin routine-chemotherapy | Drug | — | UNRESOLVED |
| induction Chrono-chemotherapy | Drug | — | UNRESOLVED |
| induction Routine-chemotherapy | Drug | — | UNRESOLVED |
| intensity-modulated radiation therapy | Radiation | — | UNRESOLVED |
| Routine intravenous drip | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Melodie group
- description
- Induction chrono-chemotherapy followed by cisplatin chrono-chemotherapy concurrent combined with intensity-modulated radiation therapy
- interventionNames
- Device: Chrono-chemotherapy pump:Melodie
- Drug: induction Chrono-chemotherapy
- Drug: cisplatin chrono-chemotherapy
- Radiation: intensity-modulated radiation therapy
- type
- OTHER
- label
- Routine-Chemotherapy
- description
- Induction routine-chemotherapy followed by cisplatin routine-chemotherapy concurrent combined with intensity-modulated radiation therapy
- interventionNames
- Device: Routine intravenous drip
- Drug: induction Routine-chemotherapy
- Drug: cisplatin routine-chemotherapy
- Radiation: intensity-modulated radiation therapy
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * initial treatment of advanced nasopharyngeal carcinoma Ⅲ-Ⅳ patients with pathologically confirmed (according to 2010 UICC staging, T3-4, N0-3), without evidence of distant metastasis (M0). Have measurable tumor lesions. * KPS≥70 points. * the age of 18-70 years old, male or female. * no major organ dysfunction; normal bone marrow function (WBC ≥4.0 × 109 / L, platelets ≥100 × 109 / L, hemoglobin ≥90g / L), normal liver function (total bilirubin, alanine aminotransferase, aspartate aminotransferase ≤1.5 times the upper limit of normal), normal renal function (creatinine ≤ 1.5 times upper limit of normal). * understand this study and signed informed consent. Exclusion Criteria: * distant metastasis. * who had received prior chemotherapy. * patients have physical or mental illness, and by researchers believe that patients can not be completely or fully understood in this study possible complications. * pregnancy (via the urine or serum β-HCG test confirmed) or during lactation. * serious complications, such as uncontrolled hypertension, heart failure, diabetes and so on.
References
Publications (0)
Data not yet available