Clinical trial · Observational
Endoscopic Evaluation for Predicting the Complications Related to Gastric Conduit After Esophagectomy
NCT02937389CI-TRIAL-00065337completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Gastric conduit ischemia or anastomotic breakdown after esophagectomy with cervical esophagogastrostomy often cause severe complications, such as leakage, necrotic organs, and strictures. Thus, the purpose of this study is the safety and efficacy of endoscopic evaluation about reconstructive organs after esophagectomy. The investigators evaluate endoscopic predictions using classifications in acute phase after esophagogastrostomy.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leak | — | UNRESOLVED | — |
| Constriction | — | UNRESOLVED | — |
| Esophageal Neoplasms | Esophageal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Ischemia | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Patients after esophagectomy | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- The classification of gastric conduit ischemia by endoscopic findings predicts the major complications of gastric conduit (strictures, leakage, necrosis)
- timeFrame
- From 1 to 29 days after esophagectomy
Secondary outcomes (3)
- measure
- Biological examination of the mucosal biopsy of gastric conduit as assessed by the ischemia related RNA copy number
- timeFrame
- From 1 to 15 days after esophagectomy
- measure
- Biological examination of the mucosal biopsy of gastric conduit as assessed by the scoring system for immunohistochemical staining
- timeFrame
- From 1 to 15 days after esophagectomy
- description
- The scoring system refer to the article entitled a scoring system for immunohistochemical staining: consensus report of the task force for basic research of the European Organization for Research and Treatment of Cancer-Gynaecological Cancer Cooperative Group
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 20 Years
- Maximum age
- 84 Years
Show eligibility criteria text
Inclusion Criteria: \- Malignant or end-stage benign esophageal disease. Esophagectomy with reconstruction by a gastric pull-up. Exclusion Criteria: \- Severe heart failure and pulmonary dysfunction Severe renal and liver dysfunction Allergenic history Pregnancy
References
Publications (1)
- DERIVEDKobayashi S, Kanetaka K, Yoneda A, Yamaguchi N, Kobayashi K, Nagata Y, Maruya Y, Yamaguchi S, Hidaka M, Eguchi S. Endoscopic mucosal ischemic index for predicting anastomotic complications after esophagectomy: a prospective cohort study. Langenbecks Arch Surg. 2023 Jan 17;408(1):37. doi: 10.1007/s00423-023-02783-x. PMID 36648542