Clinical trial · Observational
Intestinal Microbiota Survey of Polycystic Ovary Syndrome
The Cross-sectional Study of Intestinal Microbiota in Women With Polycystic Ovary Syndrome and Its Association With Clinical and Biological Parameters
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Polycystic Ovary Syndrome is kind of disease with unclear etiology. Recent studies on intestinal microbiota have raised the possibility that dysbiosis of intestinal microbiota maybe a novel theory for the development of Polycystic Ovary Syndrome. Hence, the investigators will compare the intestinal microbiota composition and diversity in PCOS with age, BMI-matched control and then assess whether intestinal microbiota modification is associated with clinical and biological parameters.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Polycystic Ovary Syndrome | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood Draw | Other | — | UNRESOLVED |
| Stool collection | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Polycystic Ovary Syndrome
- description
- Premenopausal women between 18-40 years of age. Diagnosed with PCOS using Rotterdam criteria (meet 2 of the 3): 1. chronic oligo- or amenorrhea (irregular periods during more than a year in combination with a cycle length longer than 35 days); 2. total or free T levels above the reference interval and/or excessive facial hair, acne; 3. transvaginal ultrasound with polycystic ovaries. Exclusion of common medical disorders (normal thyroid function tests and serum prolactin and exclusion of 21-hydroxylase deficiency).
- interventionNames
- Other: Blood Draw
- Other: Stool collection
- label
- Control
- description
- Women matched for age and BMI.
- interventionNames
- Other: Blood Draw
- Other: Stool collection
Primary outcomes (1)
- measure
- Intestinal microbiota of stool samples of PCOS and age, BMI-matched control will be identified by quantitative analysis.
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: 1. Premenopausal between 18-40 years of age. 2. Exclusion of other etiologies for infertility. Exclusion Criteria: 1. During the pregnancy and lactation period. 2. Use of antibiotics within 3 months. 3. Regular use of proton pump inhibitors, laxatives or pro-prebiotics. 4. Previous history of gastrointestinal surgery or disease (such as peptic ulcer, irritable bowel syndrome, inflammatory bowel disease or other gastrointestinal disorder). 5. Major changes in eating habits within the past 3 months.
References
Publications (0)
Data not yet available