Clinical trial · Interventional
Study to Evaluate the Benefit of a High Frequency Ventilation System During Lung or Breast Cancer Radiotherapy Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): due to Covid19 restrictions
Summary
Brief summary (as posted)
That study combines High Frequency Percussive Ventilation (HFPV) with radiotherapy treatment in patients with tumors that are moving with respiration like breast or lung cancers. The use of a High Frequency Percussive Ventilation system leads to the cessation of respiratory motions while administering radiotherapy (RT) to tumors which allows a reduction of the amount of irradiated normal tissues and which potentially decrease radiation-induced collateral damages.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Active Breathing Control | Other | — | UNRESOLVED |
| Free breathing | Other | — | UNRESOLVED |
| High Frequency Percussive Ventilation | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- tomotherapy (HFPV vs free breathing)
- description
- Tomotherapy: locally advanced lung cancer (Stage III) or left breast cancer. High Frequency Percussive Ventilation will be coupled to tomotherapy treatment. The alternative procedure is free breathing.
- interventionNames
- Device: High Frequency Percussive Ventilation
- Other: Free breathing
- type
- EXPERIMENTAL
- label
- linear accelerator (HFPV vs ABC)
- description
- Linear accelerator: breast cancer or pulmonary cancers (Stage I/II) requiring a stereotaxic radiotherapy. High Frequency Percussive Ventilation will be coupled to linear accelerator. The alternative procedure is Active Breathing Control (ABC).
- interventionNames
- Device: High Frequency Percussive Ventilation
- Other: Active Breathing Control
Primary outcomes (2)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * breast cancer eligible for tomotherapy or linear accelerator with ABC system * lung cancer eligible for curative tomotherapy and with a significant breathing movements amplitude * lung cancer eligible for ablative stereotaxis * WHO 0 or 1 Exclusion Criteria: * patients requiring oxygen or not able to lie on the back (dyspnea) * pulmonary functions altered * cardiac insufficiency * patient not able to breathe with the High Frequency Ventilation System * risk of pneumothorax when experiencing High Frequency Ventilation
References
Publications (0)
Data not yet available