Clinical trial · Interventional
Laparoscopy-assisted Pylorus-vagus Nerve Preserving Gastrectomy in the Treatment of Early Gastric Cancer
Laparoscopy-assisted Pylorus-vagus Nerve Preserving Gastrectomy in the Treatment of Early Gastric Cancer: Clinical Outcomes of a Randomised Controlled Trial
NCT02936193CI-TRIAL-00041452LAPPGunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The safety and efficacy of Laparoscopy-assisted Pylorus-preserving Gastrectomy (LAPPG) for the treatment of early gastric cancer (EGC) remain controversial. The investigators conducted a randomized controlled trial to compare LAPPG and laparoscopic distal gastrectomy with D2 lymph node dissections for EGC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Early Gastric Cancer | Early Gastric Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Distal gastrectomy | Procedure | — | UNRESOLVED |
| Pylorus preservation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Pylorus preservation
- description
- Patients undergo Laparoscopic Gastrectomy with Pylorus-preservation
- interventionNames
- Procedure: Pylorus preservation
- type
- ACTIVE_COMPARATOR
- label
- Distal gastrectomy
- description
- Patients undergo Laparoscopic Gastrectomy procedure detailing in distal gastrectomy with D2 lymphadenectomy
- interventionNames
- Procedure: Distal gastrectomy
Primary outcomes (1)
- measure
- Progression-free Survival
- timeFrame
- 3 years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Age older than 18 and younger than 75 years * Primary gastric adenocarcinoma confirmed pathologically by endoscopic biopsy * cT1-2N0-3M0 at preoperative evaluation according to AJCC Cancer Staging Manual, 7th Edition * Expected curative resection via distal subtotal gastrectomy with D2 lymphadenectomy * Written informed consent Exclusion Criteria: * Pregnant or breast-feeding women * Severe mental disorder * Previous upper abdominal surgery (except laparoscopic cholecystectomy) * Previous gastrectomy, endoscopic mucosal resection, or endoscopic submucosal dissection * Other malignant disease within the past 5 years * Previous neoadjuvant chemotherapy or radiotherapy * Unstable angina, myocardial infarction, or cerebrovascular accident within the past 6 months * Continuous systematic administration of corticosteroids within 1 month before the study * Requirement of simultaneous surgery for other diseases * Emergency surgery due to a complication (bleeding, obstruction, or perforation) caused by gastric cancer
References
Publications (0)
Data not yet available
No reference posted for this study.