Clinical trial · Interventional
High-Flow Oxygen for Dyspnea in Hospitalized Cancer Patients
NCT02932332CI-TRIAL-00065859completedPhase 2Results postedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical research study is to compare high-flow oxygen, low-flow oxygen, high-flow air, and low-flow air in helping to decrease shortness of breath in cancer patients. Researchers also want to learn if these therapies can help to improve lung function and quality of life.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (4)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| High-flow Air | Other | — | UNRESOLVED |
| High-flow Oxygen | Other | — | UNRESOLVED |
| Low-flow Air | Other | — | UNRESOLVED |
| Low-flow Oxygen | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (4)
- type
- ACTIVE_COMPARATOR
- label
- High-flow oxygen: Initial Therapy
- description
- 4-Period crossover therapy where initial 10 minute breathing treatment with High-flow oxygen (HFOx) is followed by 3 different breathing therapies of Low-flow oxygen (LFOx), High-flow air (HFAir), and Low-flow air (LFAir) with 10 minute washout period before subsequent treatments for a total 80 minute study period accompanied by shortness of breath questionnaires.
- interventionNames
- Other: High-flow Oxygen
- Other: Low-flow Oxygen
- Other: High-flow Air
- Other: Low-flow Air
- type
- ACTIVE_COMPARATOR
- label
- Low-flow oxygen: Initial Therapy
- description
- 4-Period crossover therapy where initial 10 minute breathing treatment with Low-flow oxygen (LFOx) is followed by 3 different breathing therapies of HFOx, HFAir, and LFAir with 10 minute washout period before subsequent treatments for a total 80 minute study period accompanied by shortness of breath questionnaires.
- interventionNames
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: 1. Diagnosis of cancer 2. Patients seen by palliative care, thoracic oncology, pulmonary medicine, or emergency care at MD Anderson Cancer Center 3. Dyspnea Numeric Rating Scale at rest \>/=3 of 10 (average over last 24 hour) 4. Non-hypoxemic (i.e. oxygen saturation \>90% on ambient air) 5. Able to communicate in English or Spanish 6. Age \>/= 18 years 7. Able to tolerate high-flow oxygen/air Exclusion Criteria: 1. Memorial Delirium Rating Scale \>13 2. Hemodynamic instability 3. Respiratory failure requiring mechanical ventilation or non-invasive ventilation 4. Frequent use of rescue opioids \>8x/day or rescue bronchodilators \>8x/day over last 24 hours 5. Currently requiring high flow oxygen for oxygenation
References
Publications (1)
- DERIVEDHui D, Hernandez F, Urbauer D, Thomas S, Lu Z, Elsayem A, Bruera E. High-Flow Oxygen and High-Flow Air for Dyspnea in Hospitalized Patients with Cancer: A Pilot Crossover Randomized Clinical Trial. Oncologist. 2021 May;26(5):e883-e892. doi: 10.1002/onco.13622. Epub 2020 Dec 15. PMID 33289276