Clinical trial · Interventional
Assessment of Oncological and Functional Outcomes After Robot Assisted Partial Nephrectomy Versus Laparoscopic Partial Nephrectomy
Robot Assisted Partial Nephrectomy (RAPN) in Selective Ischemia Versus Laparoscopic Partial Nephrectomy (LPN) in Total Ischemia: Prospective Randomized Study to Assess Oncological and Functional Outcomes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Currently, partial nephrectomy (PN) is considered as the gold standard treatment modality for small renal masses. In this setting, robot-assisted and conventional laparoscopic approaches are gaining more consensus every day. However, until now, no superiority of one technique over the other has yet been demonstrated, especially on postoperative function recovery. This study compares oncological and functional outcomes after laparoscopic partial nephrectomy versus robot assisted partial nephrectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Kidney Neoplasms | Kidney Neoplasm | ONTOLOGY_EXACT | 0.90 |
Interventions
Interventions (5)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Conventional laparoscopic instruments | Device | — | UNRESOLVED |
| Da- Vinci Robot and conventional laparoscopic instruments | Device | — | UNRESOLVED |
| Laparoscopic partial nephrectomy | Procedure | — | UNRESOLVED |
| Mannitol | Drug | — | UNRESOLVED |
| Robot assisted partial nephrectomy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Laparoscopic partial nephrectomy
- description
- 1. Inclusion criteria fulfilled: * Baseline Abdomen CT/MRI * Patient Age, Weight, Height, Co-Medication * Informed Consent * Baseline renal function (eGFR, renal scintigraphy, sCreatinine, creatinine clearance) 2. During hospitalization, one day before laparoscopic partial nephrectomy: * eGFR * sCreatinine * Hemoglobin 3. After surgery: * Assessment of eGFR 4 days after operation * Hb assessment every 6 H in the first 48 H * Assessment of adverse events * Histological Results 4. 6, 12, 24 months after intervention: * Creatinine Clearance (only performed at 6 months follow-up) * Tc-99m MAG3Dynamic Scintigraphy (only performed at 6 months follow-up) * eGFR * Assessment of adverse events * Assessment of possible recurrence * Assesment of kidney volume variation
- interventionNames
- Procedure: Laparoscopic partial nephrectomy
- Device: Conventional laparoscopic instruments
- Drug: Mannitol
- type
- ACTIVE_COMPARATOR
- label
- Robot assisted partial nephrectomy
- description
- 1. Inclusion criteria fulfilled: * Baseline Abdomen CT/MRI * Patient Age, Weight, Height, Co-Medication * Informed Consent * Baseline renal function (eGFR, renal scintigraphy, sCreatinine, creatinine clearance) 2. During hospitalization, one day before robot assisted partial nephrectomy: * eGFR * sCreatinine * Hemoglobin 3. After surgery: * Assessment of eGFR 4 days after operation * Hb assessment every 6 H in the first 48 H * Assessment of adverse events * Histological Results 4. 6, 12, 24 months after intervention: * Creatinine Clearance (only performed at 6 months follow-up) * Tc-99m MAG3Dynamic Scintigraphy (only performed at 6 months follow-up) * eGFR * Assessment of adverse events * Assessment of possible recurrence * Assesment of kidney volume variation
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Men and women \>18 years * Organ-confined renal cancer (tumor stage cT1-cT2), assessed by MRI/CT * Patient qualifies for robotic or laparoscopic partial nephrectomy * Written informed consent Exclusion Criteria: * Renal masses necessitating radical tumor nephrectomy * Patients with single kidney * Bilateral kidney cancer when simultaneously operated * Previous partial nephrectomy * Renal insufficiency: Chronic Kidney Disease (CKD) stages 4-5
References
Publications (0)
Data not yet available