Study of a Humanized Antibody Initiated 2 Months After an HLA Matched Allogenic Stem Cell Transplantation

Inclusion Criteria:

1. Patients presenting a hematological malignancy (acute myeloid leukemia, acute lymphoblastic leukemia, High risk R-IPSS myelodysplastic syndromes, multiple myeloma, chronic lymphoid leukemia, chronic myeloid leukemia, myeloproliferative neoplasm, Hodgkin lymphoma or Non-Hodgkin lymphoma) treated by allogeneic HSCT according to the following parameters :

   * Donor : HLA matched related or unrelated (10/10) donor
   * Graft : peripheral blood stem cells
   * Conditioning : All types of conditioning reduced toxicity conditioning regimens ATG as in-vivo T-cell depletion
   * GVHD prophylaxis by cyclosporine, still ongoing at full dose at the time of the inclusion
2. Patient being in one of the following post-graft situation at the time of inclusion:

   * Acute myeloid leukemia (AML) or acute lymphoblastic leukemia (ALL) patients: in morphological complete remission (CR) with less than 5% bone marrow blast count.
   * High risk R-IPSS myelodysplastic syndromes patients: with at least marrow CR with less than 5% marrow blast count.
   * Multiple myeloma patients: in at least very good partial response.
   * Chronic Lymphoid Leukemia patients: in CR.
   * Chronic Myeloid Leukemia patients: in hematological CR.
   * Myeloproliferative neoplasm patients: no criteria for disease in acceleration phase.
   * Hodgkin lymphoma or Non-Hodgkin lymphoma patients: in CR.
3. Age ≥ 18 and ≤ 70 years
4. ECOG = 0-1 or Karnofsky index ≥ 70%
5. Clinical laboratory values at screening

   * Calculated creatinine clearance (according to MDRD) \> 50 ml/min/1.73 m2
   * Independence of red blood cell transfusion
   * Platelet count \> 75 x 109/l
   * ANC \> 1 x 109/l
   * Bilirubin \< 1.5 ULN
   * ALT and AST \< 3 ULN
6. Patients (male or female) who accept and are able to use contraceptive methods recognized as highly effective throughout the study and up to 5 months after the drug administration
7. Signed informed consent of the current clinical study, prior to any protocol-specific procedure
8. Patient affiliated to the national "Social Security" regimen or beneficiary of this regimen

Non inclusion Criteria:

1. Previous history of grade ≥ II acute GVHD (Glucksberg classification)
2. Current active disease or positive serology for HIV before grafting, and/or HCV with detectable viremia and/ or HBV with positive Hbs Antigen.
3. Abnormal cardiac status with any of the following :

   * Ejection fraction (measured by ultrasound or radionuclide imaging) \< 50%
   * Unstable angina
   * Myocardial infarction within the last 6 months
   * Presence or persistence of documented congestive heart failure (New York Heart Association functional classification III-IV)
   * Arrhythmia requiring treatment and which is not stabilized by the treatment.
   * QTc ≥ 450 ms (M) or 470 ms (F) (Bazett formula)
4. Previous other allogeneic hematopoietic transplantation or solid organ transplantation
5. Any other serious concurrent uncontrolled medical disorder within 4 weeks prior to IPH2201 administration
6. Use of systemic corticosteroids ongoing or within the last 1 week prior IPH2201 admin-istration
7. Use of any investigational agent within 3 months prior to first dosing (except procedure of conditioning regimen including registered drugs combinations, i.e. Busulfan and Fludarabine or Busulfan and Endoxan)
8. History of another malignancy (except, basal cell carcinoma of the skin, or in situ cervix carcinoma, or any other malignancy in complete remission for more than 3 years since the completion of the treatment). However in the case of leukemia or MDS a previous malignancy accountable for the present disease will not be an exclusion criteria if in complete remission for more than 2 years
9. Any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.
10. Pregnant or lactating women